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Molecular and Cellular Pathobiology and Therapeutics

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Staffs

  Satoshi Fujii, M.D., Ph. D., Professor
Norio Hazemoto, Ph. D., Associate Professor
Yasuhiro Noda, Ph. D., Research Associate
Soichiro Iwaki, Ph. D., Research Associate

Research Project

 
Molecular Mechanism of Atherosclerosis
Pathobiology of Thrombosis and Development of New Therapeutics
Analysis of Pathophysiological Roles of Sphingolipids in the Development of Metabolic Syndromes
Cellular Mechanism of Wound Healing and Development of New Therapeutics

Division of Molecular and Cellular Pathobiology and Therapeutics aims to elucidate the molecular and cellular mechanisms of pathogenesis of specific diseases related to life-style changes and aging processes such as atherothrombosis, diabetes and hypertension. These research activities will enable practical applications including new drug discovery and personalized medicine. In addition, novel education/training programs integrating medical and pharmaceutical sciences are introduced for graduate students. Therapeutic management of human diseases is recently much diversified. We provide state-of-the-art knowledge and technology in functional analysis of pathobiologically important molecules in response to rapidly advancing life sciences. Research units are closely linked to each other and every graduate student will have the opportunity to acquire the most-developed knowledge and technology in life sciences and drug-discovery sciences. Considering recent high-tech and very complex therapeutic procedures in real-world medical scenes our programs provide basic and clinical research activities, including analysis of pathological mechanisms of cardiovascular diseases, potential preventive measures for obesity-related diseases, and development of investigational new drugs. The programs also provide state-of-the-art education and leading-edge research activities on basic and clinical hands-on practice of medical pharmacy, and support diversified pharmacist activities including post-graduate training.
(1) Hepatocyte growth factor implicated deeply in tissue repair and regeneration can potently induce plasminogen activator inhibitor type-1 (PAI-1), the major physiologic inhibitor of fibrinolysis and proteolysis, through USF1/2, a transcriptional factor implicated in metabolic derangements.
(2) Bioactive sphingolipid metabolites have essential roles in many aspects of the pathophysiology of metabolic syndromes, such as insulin resistance, atherosclerosis, and hypertension.

Contact Information

  Graduate School of Pharmaceutical Sciences, Nagoya City University,
3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan

TEL:+81-52-836-3451 FAX:+81-52-836-3454
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