Division of Pathobiology aims to elucidate the molecular and cellular mechanisms of pathogenesis of specific diseases related to life-style changes and aging processes such as atherosclerosis, thrombosis, diabetes and hypertension. These research activities will enable future practical applications including new drug discovery and personalized medicine. In addition, novel education/training programs integrating medical and pharmaceutical sciences are introduced for graduate students. Therapeutic management of human diseases is recently much diversified and complex. We provide state-of-the-art knowledge and technology in functional analysis of pathobiologically relevant molecules in response to rapidly advancing life sciences. Research units are closely linked to each other and every graduate student will have the opportunity to acquire the most-developed knowledge and cutting-edge technology in life sciences and drug-discovery sciences. Considering recent high-tech and very complex diagnostic and therapeutic procedures in real-world medical scenes our programs provide basic and clinical research activities, including analysis of pathological mechanisms of cardiovascular and metabolic diseases, potential preventive measures for life-style-related diseases, and development of investigational new drugs. The programs also provide state-of-the-art education and globally advanced research activities on clinical hands-on practice of medical pharmacy, and diversified pharmacist activities are strongly supported by providing continual education.