Achievement

2024
Kazuki Sato, Koki Ogawa, Tatsuaki Tagami, Tetsuya Ozeki, Photothermal therapeutic effect by gold nanostars/extracellular vesicles nanocomplex on melanoma cells . Journal of Pharmaceutical Sciences. in press.

Shinkai T, Ogawa K, Tagami T, Ozeki T, Cholic acid-mediated targeting of mRNA-LNPs improve the mRNA delivery to Caco-2 cells. Journal of Nanoparticle Research. 26(265) (2024)

Ogawa K, Aikawa O, Tagami T, Ito T, Tahara K, Kawakami S, Ozeki T, Stable and inhalable powder formulation of mRNA-LNPs using pH-modified spray-freeze drying . International Journal of Pharmaceutics 124632 (2024)

Gao M, Tagami T, Ogawa K, Ozeki T. Preparation and in vitro characterization of clofazimine-loaded albumin nanocomposite microparticles for inhalation therapy . Journal of Drug Delivery Science and Technology 93 105364 (2024)

Liu J, Tagami T, Ogawa K, Ozeki T, Development of Hollow Gold Nanoparticles for Photothermal Therapy and Their Cytotoxic Effect on a Glioma Cell Line When Combined with Copper Diethyldithiocarbamate . Biological and Pharmaceutical Bulletin 47(1) 272-278 (2024)
2023
・Suwabe S, Tagami T, Ogawa K, Ozeki T. Improved drug transfer into brain tissue via the "nose-to-brain"approach using suspension or powder formulations based on the amorphous solid dispersion technique.
European Journal of Pharmaceutics Biopharmaceutics 185 137-147 (2023).

・Yamotomo N, Tagami T, Ogawa K, Ozeki T. Arbekacin-loaded inhalable nanocomposite particles specific to Pseudomonas aeruginosa prepared using a two-solution mixing-type spray nozzle. Biol Pharm Bull. 46(2) 201-208 (2023).

・小川 昂輝, 田上 辰秋, 尾関 哲也. ナノ粒子を基盤とした医薬品の製剤開発：ナノ化医薬品と刺激応答性ドラッグデリバリーシステム, ファルマシア. 59(7): 634-638 (2023)

・田上 辰秋, 尾関 哲也.　「お薬いろいろ　～百薬百話～」　意外と知らない薬の話.　. 中日新聞社. P48-55 (2023)

・小川 昂輝, 田上 辰秋, 尾関 哲也. 「無機ナノ粒子を利用したドラッグデリバリー技術・ナノメディシンの開発」, ファインケミカル52(6): 13-19 (2023)

・田上 辰秋, 小川 昂輝, 尾関 哲也. 「口腔内崩壊錠の評価法」 製剤機械技術学会誌 製剤試験法特集号32(1): 42-47 (2023)

・田上 辰秋, 小川 昂輝, 尾関 哲也. 「温熱感受性リポソームの設計と機能性向上」 新規モダリティ医薬品. 技術情報協会. 150-159 (2023)

2022

・Ikuse M, Tagami T, Ogawa K, Ozeki T. Contamination-free milling of ketoprofen nanoparticles using mannitol medium and Hoover automatic muller: Optimization of effective design of experiment. Biol Pharm Bull. 45(11), 1706-1715 (2022).

・Tagami T, Okamura M, Ogawa K, Ozeki T. Fabrication of Mucoadhesive Films Containing Pharmaceutical Ionic Liquid and Eudragit Polymer Using Pressure-Assisted Microsyringe-type 3D Printer for Treating Oral Mucositis. Pharmaceutics 14(9), 1930 (2022).

・Takashima H, Tagami T, Kato S, Pae H, Ozeki T, Shibuya Y. Three-Dimensional Printing of an Apigenin-Loaded Mucoadhesive Film for Tailored Therapy to Oral Leukoplakia and the Chemopreventive Effect on a Rat Model of Oral Carcinogenesis. Pharmaceutics 14: 1575 (2022).

・Alghurabi H, Tagami T, Ogawa K, Ozeki T. Preparation, characterization, and in vitro evaluation of Eudragit S100-coated bile salt-containing liposomes for oral colonic delivery of budesonide. Polymers 14: 2693 (2022).

・Tagami T, Goto E, Kida R, Hirose K, Noda T, Ozeki T. Lyophilized ophthalmologic patches as novel corneal drug formulations using a semi-solid extrusion 3D printer. Int J Pharm. 617:121448 (2022).

・Ibrahim AH, Ibrahim HM, Elbahwy IA, Afouna MI, Tagami T, Ozeki T. Lyophilized tablets of felodipine-loaded polymeric nanocapsules to enhance aqueous solubility: Formulation and optimization. J Drug Deliv Sci Tec. 70:103172 (2022).

・Zenda N, Tagami T, Ozeki T. Development of a Novel Gastric Process Simulation Model: The Successful Assessment of Bioequivalence and Bioinequivalence of a Biopharmaceutics Classification System Class II Weak Acid Drug. Biol Pharm Bull. 45: 364-373 (2022).

・田上 辰秋, 小川 昂輝, 尾関 哲也. 「製剤技術による個別化医療の可能性～3Dプリンターによるオーダーメイド医薬品の製造」. Drug Delivery System. 37(4): 294-302 (2022).

・田上 辰秋, 小川 昂輝, 深水 啓朗, 尾関 哲也. 「研究・技術の開発: スプレードライ法で製造する医薬品コクリスタルに関する最近の研究」. 製剤機械技術会誌. 31(3): 14-20 (2022).
2021
・Koga K, Tagami T, Ozeki T. Gold nanoparticle-coated thermosensitive liposomes for the triggered release of doxorubicin, and photothermal therapy using a near-infrared laser.Colloids Surf A Physicochem Eng Asp. 626:127038 (2021).

・Kondo Y, Tagami T, Ozeki T. Fabrication of photosensitizer-polyethylene glycol-conjugated gold nanostars for simultaneous photothermal and photodynamic cancer therapy under near-infrared laser irradiation. J Drug Deliv Sci Tec. 66:102892 (2022).

・Tagami T, Morimura C, Ozeki T. Effective and simple prediction model of drug release from "ghost tablet" fabricated using a digital light projection-type 3D printer. Int J Pharm. 604:120721 (2021).

・Tagami T, Kuwata E, Ozeki T. Confectionery Xylitol Gum-Containing Tablets for Medical Application and the Sintering Effect on Gum Tablets.Biol Pharm Bull. 44: 1309-1315 (2021).

・Tagami T, Ito E, Kida R, Hirose K, Noda T, Ozeki T. 3D printing of gummy drug formulations composed of gelatin and an HPMC-based hydrogel for pediatric use. Int J Pharm. 594: 120118 (2021).

・田上 辰秋, 尾関 哲也. 「研究・技術の開発: 3Dプリンターを用いた錠剤以外の剤形の調製に関する最近の研究～グミ・チュアブル錠・坐剤を例に～」製剤機械技術会誌. 30(2): 19-25 (2021)

・尾関 哲也, 田上 辰秋. 「金ナノ粒子に着目したドラッグデリバリー技術・ナノメディスンの開発」薬学雑誌 141(3), 323-326 (2021)
2020
・Tagami T, Ito E, Hayashi N, Sakai N, Ozeki T. Application of 3D printing technology for generating hollow-type suppository shells. Int J Pharm. 589: 119825 (2020).

・Liu J. Tagami T, Ozeki T. Fabrication of 3D-printed fish-gelatin-based polymer hydrogel patches for local delivery of PEGylated liposomal doxorubicin. Marine Drugs. (2020).

・ Fukushige K, Tagami T, Naito M, Goto E, Hirai S, Hatayama N, Yokota H, Yasui T, Baba Y, Ozeki T. Developing spray-freeze-dried particles containing a hyaluronic acid-coated liposome-protamine-DNA complex for pulmonary inhalation. Int J Pharm. 583: 118338 (2020).

・Urano M, Kitahara M, Kishi K, Goto E, Tagami T, Fukami T, Ozeki T. Physical Characteristics of Cilostazol–Hydroxybenzoic Acid Cocrystals Prepared Using a Spray Drying Method. Crystals. 10(4): 313 (2020).

・田上 辰秋, 尾関 哲也.「第11章　各産業分野における3Dプリンタの活用事例　第4節　3Dプリンター技術によるオーダーメイド医療の可能性と3Dバイオプリンターを用いた錠剤の調製」3Dプリンタ用材料開発と造形物の高精度化（分筆）技術情報協会（電子図書）p377-384 (2020)

・田上 辰秋, 尾関 哲也. 「フロンティア研究シリーズ: 3Dプリンターを用いた医薬品の製造と患者に合わせたオーダーメイド医薬品への応用」粉体工学会誌 57, 633-639 (2020).

・田上 辰秋, 尾関 哲也. 「Additive Manufacturing技術の現在II: 3Dプリンターを利用した錠剤成形」化学工学 84(5): 243-246 (2020).

・田上 辰秋, 尾関 哲也. 「3Dプリンター医薬品・錠剤の研究に関する最近のトピックス～アカデミアの立場から～」PHARM TECH JAPAN. 36(5): 145-152 (2020).
2019
・Tagami T, Ando M, Nagata N, Goto E, Yoshimura N, Takeuchi T, Noda T, Ozeki T. Fabrication of naftopidil-loaded tablets using a semi-solid extrusion-type 3D printer, and the characteristics of the printed hydrogel and resulting tablets. J Pharm Sci. 109:907-913 (2019)

・Tagami T, Kuwata E, Sakai N, Ozeki T. Drug Incorporation into Polymer Filament using Simple Soaking Method for Tablet Preparation using Fused Deposition Modeling. Biol Pharm Bull. 42:1753-1760 (2019).

・ Nishio M, Tagami T, Taki M, Ozeki T. Effective spray drying technique to prepare nanocomposite particles by preventing the growth of needle-like simvastatin crystal. J Drug Deliv Sci Tec. 53:101188 (2019).

・Maeda R, Ito T, Tagami T, Takii T, Ozeki T. Development of dried emulsion/mannitol composite microparticles through a unique spray nozzle for efficient delivery of hydrophilic anti-tuberculosis drug against alveolar macrophages. Biol Pharm Bull. 42(11):1846-1853 (2019).

・Tagami T, Yoshimura N, Goto E, Noda T, Ozeki T. Fabrication of muco-adhesive oral films by the 3D printing of hydroxypropyl methylcellulose-based catechin-loaded formulations. Biol Pharm Bull. 42(11):1898-1905 (2019).

・Tagami T, Hayashi N, Sakai N, Ozeki T. 3D printing of unique water-soluble polymer-based suppository shell for controlled drug release. Int J Pharm. 568: 118494 (2019).
2018
・Takeuchi T, Tagami T, Fukushige K, Ozeki T. Useful properties of siRNA-coated gold nanoparticles as a mini-nanocarrier platform for intraocular administration. Journal of Drug Delivery Science and Technology. 47:411-416 (2018).

・Morikawa Y, Tagami T, Hoshikawa A, Ozeki T. The use of an efficient microfluidic mixing system for generating stabilized polymeric nanoparticles for controlled drug release. Biol Pharm Bull. 41(6):899-907 (2018).

・Tagami T, Nagata N, Hayashi N, Ogawa E, Fukushige K, Sakai N, Ozeki T. Defined drug release from 3D-printed composite tablets consisting of drug-loaded polyvinylalcohol and a water-soluble or water-insoluble polymer filler. Int J Pharm. 543(1-2): 361-367 (2018).

・Hoshikawa A, Nagira M, Tane M, Fukushige K, Tagami T, Ozeki T. Preparation of curcumin-containing α-, β-, and γ-cyclodextrin/polyethylene glycol-conjugated gold multifunctional nanoparticles and their in vitro cytotoxic effects on A549 cells. Biol Pharm Bull. 41(6):908-914 (2018).

・Fuse T, Tagami T, Tane M, Ozeki T. Effective light-triggered contents release from helper lipid-incorporated liposomes co-encapsulating gemcitabine and a water-soluble photosensitizer. Int J Pharm. 540: 50-56 (2018).

・Ibrahim S, Tagami T, Kishi T, Ozeki T. Curcumin marinosomes as promising nano-drug delivery systems for lung cancer. Int J Pharm. 540: 40-49 (2018).

・Wallin M, Tagami T, Chen L, Yang M, Chan HK. Pulmonary drug delivery to older people. Adv Drug Deliv Rev. 135. 50-61 (2018)

・Noda T, Okuda T, Mizuno R, Ozeki T, Okamoto H. Two-Step Sustained-Release PLGA/Hyaluronic Acid Gel Formulation for Intra-articular Administration.Biol Pharm Bull. 41(6):937-943 (2018).

・Alenezi A, Naito Y, Terukina T, Prananingrum W, Jinno Y, Tagami T, Ozeki T, Galli S, Jimbo R. Controlled release of clarithromycin from PLGA microparticles enhances bone regeneration in rabbit calvaria defects. J Biomed Mater Res Part B 106(1):201-208 (2018).

・田上 辰秋, 尾関 哲也.「スプレードライ法によるナノコンポジット粒子の調製と吸収剤への応用」経肺投与製剤とデバイスの開発. シーエムシー出版 (2018) In press.

・田上 辰秋, 尾関 哲也. 「バイオ医薬品のDDS～生分解性ポリマー・ハイドロゲルを用いたタンパク医薬品の薬物放出制御に関する最近の研究～」バイオ医薬品の開発と市場 2019. シーエムシー出版 (2018).

・田上 辰秋, 尾関 哲也. 「ナノメディシンに関する臨床試験の動向」「ドラッグデリバリーシステム－バイオ医薬品創成に向けた組織、細胞内、核内送達技術の開発」シーエムシー出版 p21-32 (2018)

・田上 辰秋, 尾関 哲也. 「取り巻く話題: 製剤分野における3Dプリント技術の活用：3Dプリンター錠剤・医薬品に関する最近の話題」 製剤機械技術会誌 27(1):57-62 (2018).

・田上 辰秋, 尾関 哲也. 「研究・技術の開発: 熱溶融積層方式3Dプリンターによる新しい製造アプローチとしての錠剤設計」製剤機械技術会誌 27(1):51-56 (2018).

・田上 辰秋, 尾関 哲也. 「ナノメディシン創薬の教育現場」 ファルマシア. 54(1):51-53 (2018).
2017
・Ibrahim S, Tagami T, Ozeki T. Effective-loading of platinum-chloroquine into PEGylated neutral and cationic liposomes as a drug delivery system for resistant malaria parasites. Biol Pharm Bull. (2017) 40: 815-823.

・Tagami T, Ozeki T. Recent trend of carrier-based drug delivery in clinical trials. J Pharm Sci. (2017) 106(9): 2219-2226.

・Fukushige K, Tagami T, Ozeki T. The offset effect of a hyaluronic acid coating to cationic carriers containing siRNA: Alleviated cytotoxicity and retained gene silencing in vitro. Journal of Drug Delivery Science and Technology. (2017) 39: 435-441.

・Noda T, Okuda T, Ban K, Mizuno R, Tagami T, Ozeki T, Okamoto H. Development of intra-knee joint sustained release gel formulation and evaluation of its pharmacological efficiency in rat. Biol Pharm Bull. (2017) 40(6):830-836.

・Hoshikawa A, Tagami T, Morimura C, Fukushige K, Ozeki T. Ranibizumab biosimilar/ polyethyleneglycol-conjugated gold nanoparticles as a novel drug delivery platform for age-related macular degeneration. Journal of Drug Delivery Science and Technology. (2017) 38:45-50.

・Tagami T, Fukushige K, Ogawa E, Hayashi N, Ozeki T. 3D printing factors important for the fabrication of polyvinylalcohol filament-based tablets. Biol Pharm Bull. (2017) 40(3):357-364.

・Taki M, Tagami T, Ozeki T. Preparation of polymer-blended quinine nanocomposite particles by spray drying and assessment of their instrumental bitterness-masking effect using a taste sensor. Drug Dev Ind Pharm. (2017) 43(5): 715-722.

・Tagami T, Ando Y, Ozeki T. Fabrication of liposomal doxorubicin exhibiting ultrasensitivity against phospholipase A2 for efficient pulmonary drug delivery to lung cancers. Int J Pharm. (2017) 517: 35-41.

・Yoshimura M, Miyake M, Kawato T, Bando M, Toda M, Kato Y, Fukami T, Ozeki T. Impact of the Dissolution Profile of the Cilostazol Cocrystal with Supersaturation on the Oral Bioavailability. Cryst. Growth Des. (2017) 17 (2):550–557.

・Tanetsugu T, Tagami T, Terukina T, Ogawa T, Ohta M, Ozeki T. Development of sustainable release system for ranibizumab biosimilar using poly(lactic-co-glycolic acid) biodegradable polymer based microspheres as a platform. Biol. Pharm. Bull. (2017) 40(2) :145-150.

・田上 辰秋, 尾関 哲也.「第7章 4節 PLGA粒子を用いたDDS技術の開発」最新DDS技術の先端バイオ医薬品への応用開発. 技術情報協会. (2017) 395-400.

・田上 辰秋, 尾関 哲也. 医師と薬剤師が共有すべき薬の新知識/serial 19「ナノ・マイクロ粒子のDDS技術と臨床応用」 Organ Biology. (2017) 24(1):54-60.

・田上 辰秋, 尾関 哲也.「スプレードライ法を用いた固体分散体の調製」「難溶解性薬物」の改善、製剤化技術. Pharm Stage. (2017) 17(8):29-31
2016
・Otsuka M, Maeno Y, Fukami T, Inoue M, Tagami T, Ozeki T. Solid dispersions of efonidipine hydrochloride ethanolate with improved physicochemical and pharmacokinetic properties prepared with microwave treatment. Eur J Pharm Biopharm. (2016) 108: 25-31.

・Taki M, Tagami T, Fukushige K, Ozeki T. Fabrication of nanocomposite particles using a two-solution mixing-type spray nozzle for use in an inhaled curcumin formulation. Int J Pharm. (2016) 11(1):104-10.

・Nakane D, Tagami T, Inomata T, Ichikawa Y, Nakada A, Ozeki T, Masuda H. Dissolution of water-insoluble curcumin by femtosecond-laser ablation in the presence of cyclodextrins and its cytotoxic bioactivity against lung cancer cells. Chemistry letters. (2016) 45(9):1072-1074.

・Miyahara S, Tagami T, Wakabayashi R, Miyazaki I, Murata N, Takahashi Y, Ohkubo H, Ozeki T. Manufacturing control of drugs in opaque packages using an X-ray scanning system and assessment of the irradiation effects on the drug qualities. Japan Society of Pharmaceutical Machinery and Engineering. (2016) 25(2):112-118.

・Terukina T, Naito Y, Tagami T, Morikawa, Y, Henmi Y, Pranaingrum W, Ichikawa T, Ozeki T. The effect of the release behavior of simvastatin from different PLGA particles on bone regeneration in vitro and in vivo: comparison of simvastatin-loaded PLGA microparticles and nanospeheres. Journal of Drug Delivery Science and Technology. (2016) 33: 136-142.

・Nishiyama T, Ogata T, Ozeki T. Preparation of bitter taste-masking granules of lafutidine for orally disintegrating tablets using water-insoluble/soluble polymer combinations. Journal of Drug Delivery Science and Technology. (2016) 32: 38-42.

・Tagami T, Taki M, Ozeki T. Nanoparticulate drug delivery systems to overcome the blood-brain barrier. Nanomaterials in Pharmacology. Springer. Invited review (2016) Chapter 17: 333-348.

・田上 辰秋, 尾関 哲也.「剤形の進歩：経肺投与経路を利用したインスリン吸入製剤とDDS技術」Drug Delivery System. (2016) 31(5):432-439.
2015
・Tagami T, Yanai H, Terada Y, Ozeki T. Evaluation of phosphatidylserine-specific peptide-conjugated liposomes using a model system of malaria-infected erythrocytes. Biol. Pharm. Bull. (2015) 38(10):1649-51.

・Tagami T, Kubota M, Ozeki T. Effective Remote Loading of Doxorubicin into DPPC/Poloxamer 188 Hybrid Liposome to Retain Thermosensitive Property and the Assessment of Carrier-Based Acute Cytotoxicity for Pulmonary Administration. J Pharm Sci. (2015) 104(11):3824-32.

・Mizusako H, Tagami T, Hattori K, Ozeki T. Active Drug Targeting of a Folate-Based Cyclodextrin-Doxorubicin Conjugate and the Cytotoxic Effect on Drug-Resistant Mammary Tumor Cells In Vitro. J Pharm Sci. (2015) 104(9):2934-40.

・Uehara K, Tagami T, Miyazaki I, Murata N, Takahashi Y, Ohkubo H, Ozeki T. Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment. Drug Dev Ind Pharm. (2015) 41(6):953-8.

・Otsuka M, Maeno Y, Fukami T, Inoue M, Tagami T, Ozeki T. Developmental considerations for ethanolates with regard to stability and physicochemical characterization of efonidipine hydrochloride ethanolate. CrystEngComm. (2015) 17, 7430-7436.

・田上 辰秋，尾関 哲也．「生体適合性ナノスフェア」DDSキャリア作製プロトコル集. シーエムシー出版 (2015) p205-212.
2014
・Maeno Y, Fukami T, Kawahata M, Yamaguchi K, Tagami T, Ozeki T, Suzuki T, Tomono K. Novel pharmaceutical cocrystal consisting of paracetamol and trimethylglycine, a new promising cocrystal former. Int J Pharm. (2014) 473(1-2):179-86.

・Ozeki T, Tagami T. Drug/polymer nanoparticles prepared using unique spray nozzles and recent progress of inhaled formulation. Asian J Pharm Sci. (2014) 9(5):236-43. Review.

・Tagami T, Imao Y, Ito S, Nakada A, Ozeki T. Simple and effective preparation of nano-pulverized curcumin by femtosecond laser ablation and the cytotoxic effect on C6 rat glioma cells in vitro. Int J Pharm. (2014) 468(1-2):91-6.

・Naito Y, Terukina T, Galli S, Kozai Y, Vandeweghe S, Tagami T, Ozeki T, Ichikawa T, Coelho PG, Jimbo R. The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria. Int J Pharm. (2014) 461(1-2):157-62.

・ 田上 辰秋, 尾関 哲也. 「他分野との融合・連携が生み出す新しい製剤学・ドラッグデリバリーシステム研究」 PHARM TECH JAPAN. 30(11): 135-140 (2014)

・田上 辰秋, 尾関 哲也. 「経肺投与型製剤の動向および2液混合型スプレーノズルによるナノコンポジット粒子製造技術の開発と応用」医薬ジャーナル. 50(9): 67-72 (2014)