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Organic and Medicinal Chemistry

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Staffs

  Miyata, Naoki, Ph.D., Professor
Nakagawa, Hidehiko, Ph.D., Associate professor
Suzuki, Takayoshi, Ph.D., Research Associate

Research Project

 
Development of useful organic synthetic reactions for building drug structures
Rational molecular design and synthesis of new medical leads
Structure-activity relationship study of designed and synthesized medical leads
Mechanistic study of designed and synthesized bio-functional molecules
Chemistry and biology of reactive oxygen species and oxidative stress

Oriented toward the development of medical and diagnostic drugs, the studies in medicinal chemistry and chemical biology are conducted. To find attractive lead compounds and to tune them up to novel and useful biofuctional chemicals, we practice comprehensive studies of computational molecular design, synthetic reactions, biological evaluation, and action mechanisms of biofunctional molecules on the basis of organic chemistry. Our research interest includes the development of histone deacetylase inhibitors, photoinduced nitric oxide donors, adipocyte proliferation regulating compounds, DNA methylation regulating compounds, oxidative stress regulating compounds, and so on.
The followings are brief introductions of two of our biofunctional compounds.
(1) Novel histone deaceylase inhibitors: The compounds were designed and synthesized based on molecular docking simulation. The synthesized compounds showed potent growth inhibitory activity against a certain strain of cultured human cancer cells. These compounds are expected to become a novel class of anticancer drugs.
(2) Novel photoinduced nitric oxide donors: Inspired by the photoisomerization reaction of nitorobenzene, the compounds which liberate nitric oxide in response to photoirradiation were designed and synthesized. These compounds induced cancer cell death in vitro through nitric oxide production by photoirradiation. These nitric oxide donors are expected to be used as anticancer agents and experimental tools.

Contact Information

  Graduate School of Pharmaceutical Sciences, Nagoya City University,
3-1, Tanabe-dori, Mizuho-ku, Nagoya 467-8603, Japan

TEL/FAX:+81-52-836-3407
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