【生薬学分野2019年の業績】

(原報)

Misato Ota, Junko Nakazakia, Yoshiaki Tabuch, Takahiko Ono, Toshiaki Makino
Historical and pharmacological studies on rehmannia root processing – Trends in usage and comparison of the immunostimulatory effects of its products with or without steam processing and pretreatment with liquor
Journal of Ethnopharmacology 32: 157-161 (2019) [Elsevier]

Zeynep Doğan, Kan'ichiro Ishiuchi, Toshiaki Makino, İclal Saraçoğlu
New acylated iridoid glucosides from Scutellaria glaphyrostachys Rech.f. and chemotaxonomic importance for the genus Scutellaria
Phytocheistry Letters 242: 112059 (2019) [Elsevier]

Masaaki Minami, Hiroshi Takase, Masayo Taira, Toshiaki Makino
In vitro effect of the traditional medicine Hainosan (Painongsan) on Porphyromonas gingivalis
Medicines 2019: 58 (2019) [MDPI]

Zeynep Doğan, Kan’ichiro Ishiuchi, Toshiaki Makino, İclal Saraçoğlu
Alpha-pyrone glycosides from Scutellaria salviifolia Benth
Turkish Journal of Chemistry 43(3): 972-981 (2019) [Tubitak]

Masaaki Minami, Hiroshi Takase, Mineo Nakamura, Toshiaki Makino
Methanol extract of Lonicera caerulea var. emphyllocalyx fruit has antibacterial and anti-biofilm activity against Streptococcus pyogenes in vitro
BioScience Trends 13(2): 145-151 (2019) [IRCA-BSSA]

Vahap Murat Kutluay, Kan'ichiro Ishiuchi, Toshiaki Makino, Iclal Saracoglu
Cytotoxic phenylethanoid glycosides from Digitalis davisiana Heywood: Evaluation of structure activity relationships and chemotaxonomical significance of isolated compounds
Fitoterapia 135: 90-98 (2019) [Elsevier]

Yohei Tanimura, Masato Yoshida, Kan'ichiro Ishiuchi, Masahiro Ohsawa, Toshiaki Makino
Neoline is the active ingredient of processed aconite root against murine peripheral neuropathic pain model, and its pharmacokinetics in rats
Journal of Ethnopharmacology 241: 111859 (2019) [Elsevier]

Masaaki Minami, Hiroshi Takase, Masayo Taira, Toshiaki Makino
Hainosan (painongsan) suppresses the biofilm formation of Porphyromonas gingivalis and Prevotella intermedia in vitro
Traditional Kampo Medicine 2019: 1797930 (2019) [Wiley]

Katsuhiko Masumoto, Zhiyang Quan, Kan'ichiro Ishiuchi, Takashi Matsumoto,Junko Watanabe, Toshiaki Makino
Drug interaction between shoseiryuto extract or catechins and fexofenadine through organic anion-transporting polypeptide (OATP) 1A2 in vitro
Pharmacognosy Magazine 15(61): 304-308 (2019) [Pharmacog.Net]

Fuzi Zhang, Kan'ichiro Ishiuchi, Akinori Sugiyama, Masahiro Ohsawa,Toshiaki Makino
B-ring-homo-tonghaosu, isolated from Chrysanthemum morifolium capitulum, acts as a peroxisome proliferator-activated receptor-γ agonist
Journal of Natural Medicines 73(3): 497-503 (2019) [Springer]

Vahap Murat Kutluaya, Toshiaki Makino, Makoto Inoue, Iclal Saracoglu
New knowledge about old drugs; a cardenolide type glycoside with cytotoxic effect and unusual secondary metabolites from Digitalis grandiflora Miller
Fitoterapia 134: 73-80 (2019) [Elsevier]

Kan'ichiro Ishiuchi, Osamu Morinaga, Takeshi Ohkita, Chuanting Tian, Asuka Hirasawa, Miaki Mitamura, Yasuhito Maki, Tsubasa Kondo, Tomoya Yasujima, Hiroaki Yuasa, Kiyoshi Minamizawa, Takao Namiki & Toshiaki Makino
18β-glycyrrhetyl-3-O-sulfate would be a causative agent of licorice-induced pseudoaldosteronism
Scientific Reports 9: 1587 (2019) [Nature]

Masaaki Minami, Mineo Nakamura, Toshiaki Makino
Effect of Lonicera caerulea var. emphyllocalyx extracts on murine Streptococcus pyogenes infection by modulating immune system
BioMed Research International 2019: 1797930 (2019) [Hindawi]

Toshiyuki Atsumi, Yumi Yokoyama, Takami Yokogawa, Toshiaki Makino, Isao Ohtsuka
Effects of crushed Schisandra Fruit on the content of lignans in Kampo decoction
Journal of Natural Medicines 73(2): 381-387 (2019) [Springer]

Waka Nakayama, Yukio Fujiwara, Yasuhiro Kosuge, Orawan Monthakantirat, Kazumi Fujikawa, Santi Watthana, Susumu Kitanaka, Toshiaki Makino, Kan'ichiro Ishiuchi
Phlenumdines D and E, new Lycopodium alkaloids form Phlegmariurus nummulariifolius, and their regulatory effects on macrophage differentiation during tumor development
Phytochemistry Letters 29: 98-103 (2019) [Elsevier]

Aki Yamada, Kan'ichiro Ishiuchi, Toshiaki Makino, Hazime Mizukami, Kazuyoshi Terasaka
A glucosyltransferase specific for 4-hydroxy-2,5-dimethyl-3(2H)-furanone in strawberry
Bioscience, Biotechnology, and Biochemistry 83(1): 106-113 (2019) [Taylor & Francis]

Misato Ota, Kan'ichiro Ishiuchi, Xin Xu, Masaaki Minami, Yasutaka Nagachi, MahoYagi-Utsumi, Yoshiaki Tabuchi, Shao-Qing Cai, Toshiaki Makino
The immunostimulatory effects and chemical characteristics of heated honey
Journal of Ethnopharmacology 228(10): 11-17 (2019) [Elsevier]

(学会発表)

[ポスター]

セイエド アイシャ アンバル、小菅 康弘、藤原 章雄、牧野 利明、廣瀬 大、○石内 勘一郎
ウラジロモミ落葉由来糸状菌 Penicillium decaturense RO050 より単離した新規 oxalicine アルカロイドの構造と生物活性
日本薬学会第139年会、2019年3月21日(金沢);22PO-am069S

○浅井 恒志、牧野 利明、寺坂 和祥
カラダイオウからのアントラキノン配糖化酵素の探索
日本薬学会第139年会、2019年3月21日(金沢);22PO-am069S

○柏原 郁恵、佐藤 文彦、牧野 利明、寺坂 和祥
ウマノスズクサからの MATE トランスポーターの単離及び機能解析
日本薬学会第139年会、2019年3月21日(千葉);22PO-am062S

○三田村 実秋、平澤 明日香、牧 靖人、石内 勘一郎、牧野 利明
甘草の副作用、偽アルドステロン症の真の原因物質の探索 (第5報)
日本薬学会第139年会、2019年3月21日(金沢);21PO-am062

中崎 絢子、○太田 美里、田渕 圭章、牧野 利明
地黄の修治による効能変化の本草学的考察及びその科学的検証
日本薬学会第139年会、2019年3月21日(千葉);21PO-am054

◯Xin Xu, Misato Ota, Yoshiaki Tabuchi, Shao-Qing Cai, Toshiaki Makino
Inducible effect of heated honey on G-CSF secretion from cultured intestinal cells and its active ingredients
Nagoya Immunology Network in NCU, 2019, 03, 11, Nagoya, Japan


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