【生薬学分野2018年の業績】
2007年業績
2008年業績
2009年業績
2010年業績
2011年業績
2012年業績
2013年業績
2014年業績
2015年業績
2016年業績
2017年業績
（原報）
笛木司、吉田理人、田中耕一郎、千葉浩輝、加藤憲忠、並木隆雄、柴山周乃、藤田康介、須永隆夫、松岡尚則、別府正志、牧野利明
水質がウズ煎液中のアコニチン型ジエステルアルカロイド量に及ぼす影響
日本東洋医学雑誌 69(4): 336-345 (2018)
Yuusuke Tashiro, Ryo Sakai, Tomoko Hirose-Sugiura, Yukio Kato, Hirotaka Matsuo, Tappei Takada, Hiroshi Suzuki, Toshiaki Makino
Effects of osthol isolated from Cnidium monnieri fruit on urate transporter 1
Molecules 23(11): 2837 (2018) [MDPI]
Osamu Morinaga, Kan'ichiro Ishiuchi, Takeshi Ohkita, Chuanting Tian, Asuka Hirasawa, Miaki Mitamura, Yasuhito Maki, Tomoya Yasujima, Hiroaki Yuasa, Toshiaki Makino
Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism
Scientific Reports 8: 15568 (2018) [Nature]
Hao Ni, Takashi Matsumoto, Junko Watanabe, Toshiaki Makino
Inhibitory effect of Japanese traditional Kampo formula frequently prescribed in gynecological clinics on CYP3A4
Evidence-based Complementary and Alternative Medicine 2018: 4259603 (2018) [Hindawi]
Fuzi Zhang, Anna Iwaki, Kan'ichiro Ishiuchi, Akinori Sugiyama, Masahiro Ohsawa, Toshiaki Makino
Peroxisome proliferator-activated receptor-γ agonistic effect of Chrysanthemum indicum capitulum and its active ingredients
Pharmacognosy Magazine 14(56): 461–464 (2018) [Pharmacog.Net]
Masaaki Minami, Toru Konishi, Toshiaki Makino
Effect of Hochuekkito (Buzhongyiqitang) on Nasal Cavity Colonization of Methicillin-Resistant Staphylococcus aureus in Murine Model
Medicines 5(3): 83 (2018) [MDPI]
Mai Nagasaka, Ryoko Hashimoto, Yasumichi Inoue, Kan'ichiro Ishiuchi, Michiyo Matsuno, Yuka Itoh, Muneshige Tokugawa, Nobumichi Ohoka, Daisuke Morishita, Hajime Mizukami, Toshiaki Makino, and Hidetoshi Hayashi
Anti-tumorigenic acitivity of chrysin from Oroxylum indicum via non-genotoxic p53 activation through the ATM-Chk2 pathway
Molecules 23: 1394 (2018) [MDPI]
Kan'ichiro Ishiuchi, Dai Hirose, Takuma Suzuki, Waka Nakayama, Wen-Ping Jiang, Orawan Monthakantirat, Jin-Bin Wu, Susumu Kitanaka, and Toshiaki Makino
Identification of Lycopodium alkaloids produced by an ultraviolet-irradiated strain of Paraboeremia, an endophytic fungus from Lycopodium serratum var. longipetiolatum
Journal of Natural Products 81: 1143-1147 (2018) [ACS]
Masaaki Minami, Toru Konishi, Hiroshi Takase, and Toshiaki Makino
Comparison between the effects of oral and intramuscular administration of Shin’iseihaito (Xinyiqingfeitang) in a Streptococcus pyoges-induced murine sinusitis model
Evidence-based Complementary and Alternative Medicine, in press (2018) [Hindawi]
Hui Sun, Le Yang, Meng-xi Li, Heng Fang, Ai-hua Zhang, Qi Song, Xing-yuan Liu, Jing Su, Meng-die Yu, Toshiaki Makino, Xi-jun Wang
UPLC-G2Si-HDMS untargeted metabolomics for identification of metabolic targets of Yin-Chen-Hao-Tang used as a therapeutic agent of dampness-heat jaundice syndrome
Journal of Chromatography B Analytical Technologies in the Biomedical and Life Sciences. 1081-1082: 41-50 (2018) [Elsevier]
Junji Akaki, Shiori Tachi, Naoki Nakamura, Tetsuya Arai, Hiroo Yamasaki, Makoto Inoue, Toshiaki Makino
Promotive effect of Bofutsushosan (Fangfengtongshengsan) on lipid and cholesterol excretion in feces in mice treated with a high-fat diet
Journal of Ethnopharmacology 220(28): 1-8 (2018) [Elsevier]
Shengli Gao, Hideo Satsu, Toshiaki Makino
Inhibitory effect of bofutsushosan (fang feng tong sheng san) on glucose transporter 5 function in vitro
Journal of Natural Medicines 72(2): 530-536 (2018) [Springer]
Rie Iijima, Tomoki Watanabe, Kan'ichiro Ishiuchi, Takashi Matsumoto, Junko Watanabe, Toshiaki Makino
Interactions between crude drug extracts used in Japanese traditional Kampo medicines and organic anion-transporting polypeptide 2B1
Journal of Ethnopharmacology 214(25): 153-159 (2018) [Elsevier]
Misato Ota, Yasutaka Nagachi, Kan'ichiro Ishiuchi, Yoshiaki Tabuchi, Feng Xu, Ming-Ying Shang, Shao-Qing Cai, Toshiaki Makino
Comparison of the inducible effects of licorice products with or without heat-processing and pre-treatment with honey on granulocyte colony-stimulating factor secretion in cultured enterocytes
Journal of Ethnopharmacology 214(25): 1-7 (2018) [Elsevier]
Yohta Shimato, Misato Ota, Kohshi Asai, Toshiyuki Atsumi, Yoshiaki Tabuchi, Toshiaki Makino
Comparison of byakujutsu (Atractylodes rhizome) and sojutsu (Atractylodes lancea rhizome) on anti-inflammatory and immunostimulative effects in vitro
Journal of Natural Medicines 72(1): 192-201 (2018) [Springer]
（学会発表）
[受賞講演]
○石内勘一郎
植物由来有用二次代謝産物を生産する内生糸状菌の探索
第22回天然薬物の開発と応用シンポジウム、2018,年9月7日（熊本）；平成30年度日本薬学会生薬天然物部会奨励研究賞
[口頭]
◯Yuya Ono, Dai Hirose, Susumu Kitanaka, Toshiaki Makino, Kan’ichiro Ishiuchi
Structure of a new sesquiterpenoid isolated from Colletotrichum gloeosporioides Ls29YO050, a Lycopodiaceae plant-derived endophytic fungus
The 8th Nanjing/Nagoya/Shenhang Symposium of Pharmaceutical Sciences, 2018, 10, 25, Nanjing, China
○Takuma Suzuki, Dai Hirose, Waka Nakayama, Wen-Ping Jiang, Orawan Monthakantirat, Jin-Bin Wu, Susumu Kitanaka, Toshiaki Makino, Kan’ichiro Ishiuchi
Identification of Lycopodium Alkaloids Produced by Paraboeremia sp. Lsl3KI076, an Endophytic Fungus from Lycopodium serratum var. longipetiolatum
The 8th Nanjing/Nagoya/Shenhang Symposium of Pharmaceutical Sciences, 2018, 10, 25, Nanjing, China
○Muneshige Tokugawa, Yuka Itoh, Kan’ichiro Ishiuchi, Michiyo Matsuno, Hajime Mizukami, Toshiaki Makino, Yasumichi Inoue, Hidetoshi Hayashi
Identification and characterization of novel compounds that contribute to regulate endoplasmic reticulum stress response
The 8th Nanjing/Nagoya/Shenhang Symposium of Pharmaceutical Sciences, 2018, 10, 25, Nanjing, China
○Hao Ni, Takashi Matsumoto, Junko Watanabe,Toshiaki Makino
Inhibitory effect of Japanese traditional Kampo formula frequently prescribed in gynecological clinics on CYP3A4
The 8th Nanjing/Nagoya/Shenhang Symposium of Pharmaceutical Sciences, 2018, 10, 25, Nanjing, China
○許鑫、太田美里、田渕圭章、牧野利明
G-CSF産生誘導活性を指標とした蜜炙法に適したハチミツの探索
天然薬物研究方法論アカデミー第２１回研究集会、2018,年9月3日（愛知）；O5-1
◯平澤明日香、三田村実秋、牧 靖人 、石内勘一郎、森永 紀、保嶋智也、湯浅博昭、牧野利明
甘草の副作用、偽アルドステロン症の真の原因物質の探索(第3報)
第３５回和漢医薬学会学術大会、2018,年9月1日（岐阜）；O5-1
○南 正明、平雅代、牧野利明
排膿散エキスおよびその構成生薬エキスの歯周病菌に対する抗菌作用
第３５回和漢医薬学会学術大会、2018,年9月1日（岐阜）；O7-2
○德川宗成、伊藤友香、石内勘一郎、牧野利明、松野倫代、井上靖道、林秀敏
小胞体ストレスを軽減する化合物の同定とその作用機序の解明
日本薬学会第138年会、2018,年3月27日（金沢）；27J-pm24S
○太田美里、長地康孝、石内勘一郎、田渕圭章、蔡少青、牧野利明
蜜炙による甘草のG-CSF産生誘導活性の増強機構
日本薬学会第138年会、2018,年3月26日（金沢）；26T-am04
[ポスター]
○Masaaki Minami, Masayo Taira, Toshiaki Makino
Ulcer-healing effect of jumihaidokuto (十味敗毒湯) in mouse skin ulcer model due to MRSA infection
The 19th International Congress of Oriental Medicine, 2018, 11, 24-26, Taipei, Taiwan
Kan'ichiro Ishiuchi, Osamu Morinaga, Takeshi Ohkita, Chuanting Tian, Asuka Hirasawa, Miaki Mitamura, Yasuhito Maki, Tomoya Yasujima, Hiroaki Yuasa, Takao Namiki, Kiyoshi Minamizawa, ○Toshiaki Makino
18β-glycyrrhetyl-3-O-sulfate would be a causative agent in licorice-induced pseudoaldosteronism
The 19th International Congress of Oriental Medicine, 2018, 11, 24-26, Taipei, Taiwan
○Xin Xu, Misato Ota, Yoshiaki Tabuchi, Shao-Qing Cai, Toshiaki Makino
Mechanisms of honey-processing (蜜炙) in traditional Chinese nedicine: Its inducible effects on G-CSF secretion from cultured intestinal cells
The 19th International Congress of Oriental Medicine, 2018, 11, 24-26, Taipei, Taiwan
○Tsukasa Fueki, Koichiro Tanaka, Koki Chiba, Takao Namiki, Takanori Matsuoka, Masashi Beppu, Toshiaki Makino
Influence of water properties on the contents of aconitine-type diester alkaloids in the decoctions of unprocessed aconite root
The 19th International Congress of Oriental Medicine, 2018, 11, 24-26, Taipei, Taiwan
○Toshiyuki Atsumi, Yumi Yokoyama, Takami Yokogawa, Toshiaki Makino, Isao Ohtsuka
Effects of crushed Schisandra Fruit on the content of lignans in Kampo decoction
The 19th International Congress of Oriental Medicine, 2018, 11, 24-26, Taipei, Taiwan
○森永紀、近藤翼、石内勘一郎、三田村実秋、牧野利明
甘草の副作用、偽アルドステロン症の真の原因物質の探索 (第４報)
日本生薬学会第６５回年会、2018,年9月17日（岐阜）；2P37
○太田美里、倪昊、森口翔平、大岩優貴、牧野利明
カノコソウおよびセイヨウカノコソウ含有成分とGABAA受容体結合活性の相関
日本生薬学会第６５回年会、2018,年9月17日（岐阜）；2P74
◯石内勘一郎、廣瀬大、牧野利明
アカマツ落葉由来糸状菌 Mariannaea elegans NBRC102301より単離した新規環状ペプチドの構造
日本生薬学会第６５回年会、2018,年9月16日（岐阜）；1P37
○谷村陽平、吉田理人、石内勘一郎、大澤匡弘、牧野利明
加工ブシ成分、benzoylmesaconineとneolineの体内動態および神経障害性疼痛に対する作用の比較検討
第３５回和漢医薬学会学術大会、2018,年9月1日（岐阜）；P4-1
石内勘一郎、森永紀、田川テイ、大北剛、○牧野利明
甘草の副作用、偽アルドステロン症の真の原因物質の探索 (第２報)
日本薬学会第138年会、2018,年3月27日（金沢）；27PA-am224
中山和香、Orawan Monthakantirat、藤川和美、Santi Watthana、北中進、牧野利明、○石内勘一郎
Phlegmariurus nummulariifoliusより単離した新規リコポジウムアルカロイドの構造
日本薬学会第138年会、2018,年3月27日（金沢）；27PA-pm220