病態解析学分野 | 最近の業績

最近の業績

2018

Fuji H, Ohmae S, Noma N, Takeiri M, Yasutomi H, Izumi K, Ito M, Toyomoto M, Iwaki S, Takemoto K, Seo S, Taura K, Hida S, Aoyama M, Ishihama Y, Hagiwara M, Takeda N, Hatano E, Iwaisako K, Uemoto S, Asagiri M.
Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation.
Biochem Biophys Res Commun.
2018, in press.

Kawaguchi Y, Waguri-Nagaya Y, Tatematsu N, Oguri Y, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T.
The Janus kinase inhibitor tofacitinib inhibits TNF-α-induced gliostatin expression in rheumatoid fibroblast-like synoviocytes.
Clin Exp Rheumatol.
2018, in press.

2017

Inagaki Y, Kubota E, Mori Y, Aoyama M, Kataoka H, Johnston RN, Joh T.
Anti-tumor efficacy of oncolytic reovirus against gastrointestinal stromal tumor cells.
Oncotarget.
2017 Dec 18;8(70):115632-115646.

Yamamoto G, Taura K, Iwaisako K, Asagiri M, Ito S, Koyama Y, Tanabe K, Iguchi K, Satoh M, Nishio T, Okuda Y, Ikeno Y, Yoshino K, Seo S, Hatano E, Uemoto S.
Pancreatic Stellate Cells Have Distinct Characteristics From Hepatic Stellate Cells and Are Not the Unique Origin of Collagen-Producing Cells in the Pancreas.
Pancreas.
2017 Oct;46(9):1141-1151.

Sarashina-Kida H, Negishi H, Nishio J, Suda W, Nakajima Y, Yasui-Kato M, Iwaisako K, Kang S, Endo N, Yanai H, Asagiri M, Kida H, Hattori M, Kumanogoh A, Taniguchi T.
Gallbladder-derived surfactant protein D regulates gut commensal bacteria for maintaining intestinal homeostasis.
Proc Natl Acad Sci U S A.
2017 Sep 19;114(38):10178-10183.

Tatematsu N, Waguri-Nagaya Y, Kawaguchi Y, Oguri Y, Ikuta K, Kobayashi M, Nozaki M, Asai K, Aoyama M, Otsuka T.
Mithramycin has inhibitory effects on gliostatin and matrix metalloproteinase expression induced by gliostatin in rheumatoid fibroblast-like synoviocytes.
Mod Rheumatol.
2017 Jul 25:1-11.

Sanagawa A, Ogasawara M, Kusahara Y, Yasumoto M, Iwaki S, Fujii S.
Investigation into Differences in Level of Knowledge about Hypertension between High School Students and Elderly People.
Yakugaku Zasshi.
2017;137(6):783-789.

Nishio T, Taura K, Iwaisako K, Koyama Y, Tanabe K, Yamamoto G, Okuda Y, Ikeno Y, Yoshino K, Kasai Y, Okuno M, Seo S, Sakurai T, Asagiri M, Hatano E, Uemoto S.
Hepatic vagus nerve regulates Kupffer cell activation via α7 nicotinic acetylcholine receptor in nonalcoholic steatohepatitis.
J Gastroenterol.
2017 Aug;52(8):965-976.

Ohmae S, Noma N, Toyomoto M, Shinohara M, Takeiri M, Fuji H, Takemoto K, Iwaisako K, Fujita T, Takeda N, Kawatani M, Aoyama M, Hagiwara M, Ishihama Y, Asagiri M.
Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K.
Sci Rep.
2017 Mar 16;7:41710.

Tamura T, Aoyama M, Ukai S, Kakita H, Sobue K, Asai K.
Neuroprotective erythropoietin attenuates microglial activation, including morphological changes, phagocytosis, and cytokine production.
Brain Res.
2017 May 1;1662:65-74.

2016

Sanagawa A, Iwaki S, Asai M, Sakakibara D, Norimoto H, Sobel BE, Fujii S.
Sphingosine 1‐phosphate induced by hypoxia increases the expression of PAI‐1 in HepG2 cells via HIF‐1α.
Mol Med Rep.
2016 Aug;14(2):1841-8.

Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, Miyazawa H, Yamaguchi Y, Miura M, Jenkins DM, Choi H, Kim JW, Asagiri M, Cowburn AS, Abe H, Soma K, Koyama K, Katoh M, Sayama K, Goda N, Johnson RS, Manabe I, Nagai R, Komuro I.
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity.
Nat Commun.
2016 May 18;7:11635.

Zhao C, Ichimura A, Qian N, Iida T, Yamazaki D, Noma N, Asagiri M, Yamamoto K, Komazaki S, Sato C, Aoyama F, Sawaguchi A, Kakizawa S, Nishi M, Takeshima H.
Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization.
Sci Signal.
2016 May 17;9(428):ra49.

Fujita T, Soontrapa K, Ito Y, Iwaisako K, Moniaga CS, Asagiri M, Majima M, Narumiya S.
Hepatic stellate cells relay inflammation signaling from sinusoids to parenchyma in mouse models of immune-mediated hepatitis.
Hepatology.
2016 Apr;63(4):1325-39.

Almaden JV, Liu YC, Yang E, Otero DC, Birnbaum H, Davis-Turak J, Asagiri M, David M, Goldrath AW, Hoffmann A.
B-cell survival and development controlled by the coordination of NF-κB family members RelB and cRel.
Blood.
2016 Mar 10;127(10):1276-86.

Goto Y, Aoyama M, Sekiya T, Kakita H, Waguri-Nagaya Y, Miyazawa K, Asai K, Goto S.
CXCR4+CD45- cells are niche forming for osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 signaling pathways in bone marrow.
Stem Cells.
2016 in press.

Suzuki M, Cao K, Kato S, Komizu Y, Mizutani N, Tanaka K, Arima C, Tai MC, Yanagisawa K, Togawa N, Shiraishi T, Usami N, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Igarashi Y, Inokuchi JI, Iwaki S, Fujii S, Satou A, Matsumoto Y, Ueoka R, Tamiya-Koizumi K, Murate T, Nakamura M, Kyogashima M, Takahashi T.
Targeting CERS6-dependent Metastasis-prone Phenotype in Lung Cancer Cells.
J Clin Invest.
2016 Jan;126(1):254-65.

2015

Tanabe K, Taura K, Koyama Y, Yamamoto G, Nishio T, Okuda Y, Nakamura K, Toriguchi K, Takemoto K, Yamanaka K, Iwaisako K, Seo S, Asagiri M, Hatano E, Uemoto S.
Migration of splenic lymphocytes promotes liver fibrosis through modification of T helper cytokine balance in mice.
J Gastroenterol.
2015 Oct;50(10):1054-68.

Mizutani N, Inoue M, Omori Y, Ito H, Tamiya-Koizumi K, Takagi A, Kojima T, Nakamura M, Iwaki S, Nakatochi M, Suzuki M, Nozawa Y, Murate T.
Increased Acid Ceramidase Expression depends on Upregulation of Androgen-dependent Deubiquitinases, USP2, in a Human Prostate Cancer Cell Line, LNCaP.
J Biochem.
2015 Oct;158(4):309-19.

Ochiya T, Takenaga K, Asagiri M, Nakano K, Satoh H, Watanabe T, Imajoh-Ohmi S, Endo H.
Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction.
Mol Ther Methods Clin Dev.
2015 Apr 1;2:15008.

Noma N, Asagiri M, Takeiri M, Ohmae S, Takemoto K, Iwaisako K, Minato N, Maeda-Yamamoto M, Simizu S, Umezawa K.
Inhibition of MMP-2-Mediated Mast Cell Invasion by NF-κB Inhibitor DHMEQ in Mast Cells.
Int Arch Allergy Immunol.
2015 Apr 1;2:15008.

Sugiura T, Dohi Y, Yamashita S, Iwaki S, Ito S, Sanagawa A, Ohte N, Fujii S.
Circulating Level of MicroRNA-126 may be a Potential Biomarker for Recovery from Smoking-Related Vascular Damage in Middle-Aged Habitual Smokers.
IJC Heart & Vasculature.
2015 7:83−87.

Hamano S, Mori Y, Aoyama M, Kataoka H, Tanaka M, Ebi M, Kubota E, Mizoshita T, Tanida S, Johnston RN, Asai K, Joh T.
Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells.
Cancer Lett.
2015 Jan 28;356(2 Pt B):846-54.

2014

Nagaya Y, Aoyama M, Tamura T, Kakita H, Kato S, Hida H, Saitoh S, Asai K.
Inflammatory cytokine tumor necrosis factor α suppresses neuroprotective endogenous erythropoietin from astrocytes mediated by hypoxia-inducible factor-2α.
Eur J Neurosci.
2014 Dec;40(11):3620-6.

Ito S, Iwaki S, Kondo R, Satoh M, Iwabuchi K, Ohkawa R, Mishima Y, Yatomi Y, Furumoto T, Tsutsui H, Fujii S.
TNF-α production in NKT cell hybridoma is regulated by sphingosine-1-phosphate: implications for inflammation in atherosclerosis.
Coron Artery Dis.
2014 Jun;25(4):311-20.

Xia H, Yamada S, Aoyama M, Sato F, Masaki A, Ge Y, Ri M, Ishida T, Ueda R, Utsunomiya A, Asai K, Inagaki H.
Prognostic impact of microRNA-145 down-regulation in adult T-cell leukemia/lymphoma.
Hum Pathol.
2014 Jun;45(6):1192-8.

Nomura T, Aoyama M, Waguri-Nagaya Y, Goto Y, Suzuki M, Miyazawa K, Asai K, Goto S.
Tumor necrosis factor stimulates osteoclastogenesis from human bone marrow cells under hypoxic conditions.
Exp Cell Res.
2014 Feb 15;321(2):167-77.

2013

Ito S, Iwaki S, Koike K, Yuda Y, Nagasaki A, Ohkawa R, Yatomi Y, Furumoto T, Tsutsui H, Sobel BE, Fujii S.
Increased plasma sphingosine-1-phosphate in obese individuals and its capacity to increase the expression of plasminogen activator inhibitor-1 in adipocytes.
Coron Artery Dis.
2013 Dec;24(8):642-50.

Mizutani N, Kobayashi M, Sobue S, Ichihara M, Ito H, Tanaka K, Iwaki S, Fujii S, Ito Y, Tamiya-Koizumi K, Takagi A, Kojima T, Naoe T, Suzuki M, Nakamura M, Banno Y, Nozawa Y, Murate T.
Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB.
Biochim Biophys Acta.
2013 May;1833(5):1006-16.

Kakita H, Aoyama M, Nagaya Y, Asai H, Hussein MH, Suzuki M, Kato S, Saitoh S, Asai K.
Diclofenac enhances proinflammatory cytokine-induced phagocytosis of cultured microglia via nitric oxide production.
Toxicol Appl Pharmacol.
2013 Apr 15;268(2):99-105.

Asai H, Kakita H, Aoyama M, Nagaya Y, Saitoh S, Asai K.
Diclofenac enhances proinflammatory cytokine-induced aquaporin-4 expression in cultured astrocyte.
Cell Mol Neurobiol.
2013 Apr;33(3):393-400.

2012

Aoyama M, Kakita H, Kato S, Tomita M, Asai K.
Region-specific expression of a water channel protein, aquaporin 4, on brain astrocytes.
J Neurosci Res.
2012 Dec;90(12):2272-80.

Kako E, Kaneko N, Aoyama M, Hida H, Takebayashi H, Ikenaka K, Asai K, Togari H, Sobue K, Sawamoto K.
Subventricular zone-derived oligodendrogenesis in injured neonatal white matter in mice enhanced by a nonerythropoietic erythropoietin derivative.
Stem Cells.
2012 Oct;30(10):2234-47.

Sun X, Zhang M, Sanagawa A, Mori C, Ito S, Iwaki S, Satoh H, Fujii S.
Circulating microRNA-126 in patients with coronary artery disease: correlation with LDL cholesterol.
Thromb J.
2012 Aug 28;10(1):16.

Iwaki S, Yamamura S, Asai M, Sobel BE, Fujii S.
Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by sphingosine 1-phosphate in HepG2 liver cells.
Biochim Biophys Acta.
2012 Jul 20;1819(11-12):1132-1141.

Tanaka K, Tamiya-Koizumi K, Hagiwara K, Ito H, Takagi A, Kojima T, Suzuki M, Iwaki S, Fujii S, Nakamura M, Banno Y, Kannagi R, Tsurumi T, Kyogashima M, Murate T.
Role of down-regulated neutral ceramidase during all-trans retinoic acid induced neuronal differentiation in SH-SY5Y neuroblastoma cells.
J Biochem. 2012 Jun;151(6):611-620.

Sugiura T, Dohi Y, Yamashita S, Ohte N, Ito S, Iwaki S, Hirowatari Y, Ohkawa R, Mishima Y, Yatomi Y, Kimura G, Fujii S.
Analytical evaluation of plasma serotonin and sphingosine 1-phosphate and their clinical assessment in early atherosclerosis.
Coron Artery Dis. 2012 Jun;23(4):234-8.

Ikuta K, Waguri-Nagaya Y, Kikuchi K, Yamagami T, Nozaki M, Aoyama M, Asai K, Otsuka T.
The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes.
Arthritis Res Ther. 2012 Apr 25;14(2):R87.

2011

Asakura T, Iwaki S, Okada H, Sobel BE, Fujii S.
Posttranscriptional regulation of expression of plasminogen activator inhibitor type-1 by cAMP in HepG2 liver cells.
J Biochem. 2011 Dec;150(6):687-94.

Nakayama N, Nakamura T, Okada H, Iwaki S, Sobel BE, Fujii S.
Modulators of induction of plasminogen activator inhibitor type-1 in HepG2 cells by transforming growth factor-β.
Coron Artery Dis. 2011 Nov;22(7):468-78.

Kubota E, Kataoka H, Tanaka M, Okamoto Y, Ebi M, Hirata Y, Murakami K, Mizoshita T, Shimura T, Mori Y, Tanida S, Kamiya T, Aoyama M, Asai K, Joh T.
ERas enhances resistance to CPT-11 in gastric cancer.
Anticancer Res. 2011 Oct;31(10):3353-60.

Kato S, Aoyama M, Kakita H, Hida H, Kato I, Ito T, Goto T, Hussein MH, Sawamoto K, Togari H, Asai K.
Endogenous erythropoietin from astrocyte protects the oligodendrocyte precursor cell against hypoxic and reoxygenation injury.
J Neurosci Res. 2011 Oct;89(10):1566-74.

McPherson CA, Aoyama M, Harry GJ.
Interleukin (IL)-1 and IL-6 regulation of neural progenitor cell proliferation with hippocampal injury: differential regulatory pathways in the subgranular zone (SGZ) of the adolescent and mature mouse brain.
Brain Behav Immun. 2011 Jul;25(5):850-62.

Yamagami T, Waguri-Nagaya Y, Ikuta K, Aoyama M, Asai K, Otsuka T.
FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes.
Rheumatol Int. 2011 Jul;31(7):903-9.

2010

Aoyama M, Kataoka H, Kubota E, Tada T, Asai K.
Resistance to chemotherapeutic agents and promotion of transforming activity mediated by embryonic stem cell-expressed Ras (ERas) signal in neuroblastoma cells.
Int J Oncol. 2010 Oct;37(4):1011-6.

Kubota E, Kataoka H, Aoyama M, Mizoshita T, Mori Y, Shimura T, Tanaka M, Sasaki M, Takahashi S, Asai K, Joh T.
Role of ES cell-expressed Ras (ERas) in tumorigenicity of gastric cancer.
Am J Pathol. 2010 Aug;177(2):955-63.

Nagahara M, Waguri-Nagaya Y, Yamagami T, Aoyama M, Tada T, Inoue K, Asai K, Otsuka T.
TNF-α-induced aquaporin 9 in synoviocytes from patients with OA and RA.
Rheumatology (Oxford). 2010 May;49(5):898-906.

Miyagawa R, Asakura T, Nakamura T, Okada H, Iwaki S, Sobel BE, Fujii S.
Increased expression of plasminogen activator inhibitor type-1 (PAI-1) in HepG2 cells induced by insulin mediated by the 3'-untranslated region of the PAI-1 gene and its pharmacologic implications.
Coron Artery Dis. 2010 May;21(3):144-150.

2009

Waguri-Nagaya Y, Yamagami T, Tsuchiya A, Nozaki M, Goto H, Kobayashi M, Aoyama M, Tada T, Otsuka T.
Silicone-induced foreign-body reaction after first metatarsophalangeal joint arthroplasty for Jaccoud's arthropathy.
Rheumatol Int. 2009 Sep;29(11):1367-71.

Ohara K, Aoyama M, Fujita M, Sobue K, Asai K.
Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes.
Neurosci Lett. 2009 Sep 22;462(2):109-12.

Kakita H, Aoyama M, Hussein MH, Kato S, Suzuki S, Ito T, Togari H, Asai K.
Diclofenac enhances proinflammatory cytokine-induced nitric oxide production through NF-kappaB signaling in cultured astrocytes.
Toxicol Appl Pharmacol. 2009 Jul 1;238(1):56-63.

Nakao K, Aoyama M, Fukuoka H, Fujita M, Miyazawa K, Asai K, Goto S.
IGF2 modulates the microenvironment for osteoclastogenesis.
Biochem Biophys Res Commun. 2009 Jan 16;378(3):462-6.