List of Presentations [ 1) Contributed
presentations
2) Invited presentations 3) Lectures ]
1) Contributed presentations
- Kanichiro Ishiuchi, Osamu Morinaga, Tsuyoshi Ohkita, Chuanting Tian, Asuka
Hirasawa, Miaki Mitamura, Yasuhito Maki, Tomoya Yasujima, Hiroaki Yuasa,
Takao Namiki, Kiyoshi Minamizawa, Toshiaki Makino
18β-glycyrrhetyl-3-O-sulfate would be a causative agent in
licorice-induced pseudoaldosteronism.
The 19th International Congress of Oriental Medicine, Nov. 24 - 26, 2018
(Taipei, Taiwan).
Poster #, PB05.
- Shuya Tajima, Tomoya Yasujima, Takahiro Yamashiro, Kinya Ohta, Hiroaki
Yuasa
Functional characteristics of human renal organic cation transporters for
histamine transport.
The 8th Nanjing/Nagoya/Shenyang Symposium of Pharmaceutical Sciences, Oct.
25 - 26, 2018 (Nanjin, China).
Abstracts, p. 38 (O-24).
- Risa Takenaka, Tomoya Yasujima, Takahiro Yamashiro, Kinya Ohta, Katsuhisa
Inoue, Hiroaki Yuasa
Utilization of decynium-22 as an ENBT1-specific inhibitor for evaluation of
ENBT1-mediated nucleobase uptake in cellular systems.
The 8th Nanjing/Nagoya/Shenyang Symposium of Pharmaceutical Sciences, Oct.
25 - 26, 2018 (Nanjin, China).
Abstracts, p. 15 (O-1).
- Yutaro Shinoda, Tomoya Yasujima, Takahiro Yamashiro, Hiroaki Yuasa
Comparative analysis of the affinities of polyamines for the
carrier-mediated polyamine transport system in differentiated THP-1 cells.
2018 International Meeting on 22nd MDO/33rd JSSX, Oct. 1 - 5, 2018
(Kanazawa, Japan).
Abstracts, p. 306 (P-081).
- Shuya Tajima, Shigehiro Kawamura, Hitomi Sasaki, Tomoya Yasujima, Kinya
Ohta, Hiroaki Yuasa
Comparison of histamine recognition of OCT2 and MATE 1 in human and rat.
2018 International Meeting on 22nd MDO/33rd JSSX, Oct. 1 - 5, 2018
(Kanazawa, Japan).
Abstracts, p. 305 (P-080).
- Tomoya Yasujima, Hiroaki Yuasa, Kinya Ohta, Katsuhisa Inoue
Utilization of an SNBT1-transfected cell system for the assessment of urate
efflux transporters.
2018 International Meeting on 22nd MDO/33rd JSSX, Oct. 1 - 5, 2018
(Kanazawa, Japan).
Abstracts, p. 303 (P-076).
- Takahiro Yamashiro, Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki
Yuasa
Species difference in the sensitivity of PCFTs to the sustained inhibitory
action of myricetin: role of G158 residue.
2018 International Meeting on 22nd MDO/33rd JSSX, Oct. 1 - 5, 2018
(Kanazawa, Japan).
Abstracts, p. 303 (P-075).
- Riko Namba, Tomoya Yasujima, Takahiro Yamashiro, Hiroaki Yuasa
Functional characterization of the carrier-mediated nicotinamide transport
system in Caco-2 cells.
2018 International Meeting on 22nd MDO/33rd JSSX, Oct. 1 - 5, 2018
(Kanazawa, Japan).
Abstracts, p. 301 (P-071).
- Risa Takenaka, Yosuke Hishikawa, Tomoya Yasujima, Kinya Ohta, Katsuhisa
Inoue, Hiroaki Yuasa
Evaluation of decynium-22 as a specific inhibitor of ENBT1.
21st North American ISSX Meeting, Sept. 24 - 28, 2017 (Providence, Rhode
Island, U.S.A.).
Abstracts, p. 148 (P215).
- Yoshihisa Mimura, Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki
Yuasa
Evaluation of transcellular transport of atenolol in polarized MDCKII cells
stably expressing human PMAT and OCT1.
21st North American ISSX Meeting, Sept. 24 - 28, 2017 (Providence, Rhode
Island, U.S.A.).
Abstracts, p. 147 (P214).
- Takahiro Yamashiro, Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki
Yuasa
Identification of the amino acid residue responsible for the flavonoid
sensitivity of human proton-coupled folate transporter.
21st North American ISSX Meeting, Sept. 24 - 28, 2017 (Providence, Rhode
Island, U.S.A.).
Abstracts, p. 41 (A10); poster awards finalists; best presentation award,
third place.
- Tomoya Yasujima, Yoshihisa Mimura, Kinya Ohta, Katsuhisa Inoue, Hiroaki
Yuasa
Atenolol transport by plasma membrane monoamine transporter (SLC29A4)
and its inhibition by flavonoids contained in apple juice.
The 7th Nagoya/Nanjing/Shenyang
Symposium of Pharmaceutical Sciences, Sept. 24 - 25, 2016 (Nagoya, Japan).
Abstract P-40.
- Takahiro Yamashiro, Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki
Yuasa
The inhibitory effect of flavonoids on PCFTs: comparison between human
PCFT and rat PCFT.
The 7th Nagoya/Nanjing/Shenyang Symposium of
Pharmaceutical Sciences, Sept. 24 - 25, 2016 (Nagoya, Japan).
Abstract P-39.
- Takanori Ishiyama, Kinya Ohta, Katsuhisa Inoue, Hiroaki Yuasa: Functional
characterization of carrier-mediated folate transport system in isolated rat
renal lysosomes. 19th NA ISSX/29th JSSX Meeting, Oct. 19 - 23, 2014 (San
Francisco, California, U.S.A.); Abstracts, pp. 299-300 (P514).
- Tomomi Yamada, Katsuhisa Inoue, Kinya Ohta, Hiroaki Yuasa: Functional
characterization of a transporter capable of transporting 4-MU-Glu as a
model glycoside in HEK293 cells. 19th NA ISSX/29th JSSX Meeting, Oct. 19 -
23, 2014 (San Francisco, California, U.S.A.); Abstracts, p. 299 (P512).
- Junji Furukawa, Katsuhisa Inoue, Kinya Ohta, Hiroaki Yuasa: Functional
characterization of a novel nucleobase transporter: cooperation with salvage
enzymes in cellular nucleobase utilization. 19th NA ISSX/29th JSSX Meeting,
Oct. 19 - 23, 2014 (San Francisco, California, U.S.A.); Abstracts, p. 298
(P511).
- Takahiro Yamashiro, Kinya Ohta, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki
Yuasa: Effect of myricetin on riboflavin transporter 3. 19th NA ISSX/29th
JSSX Meeting, Oct. 19 - 23, 2014 (San Francisco, California, U.S.A.);
Abstracts, p. 297 (P509).
- Kentaro Tajima, Kanako Mizuno, Kinya Ohta, Hiroaki Yuasa: Carrier-mediated
uptake of adenine in Caco-2 cells. 19th NA ISSX/29th JSSX Meeting, Oct. 19 -
23, 2014 (San Francisco, California, U.S.A.); Abstracts, pp. 296 - 297
(P507).
- Yoshihisa Mimura, Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki
Yuasa: Atenolol transport by organic cation transporter 1 and its
interference by flavonoids. 19th NA ISSX/29th JSSX Meeting, Oct. 19 - 23,
2014 (San Francisco, California, U.S.A.); Abstracts, p. 280 (P473).
- Hiroaki Yuasa, Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro
Yamashiro, Kinya Ohta, Yayoi Hayashi: Sustained inhibitory effect of
myricetin on folate trasnport by proton-coupled folate transporter. 19th NA
ISSX/29th JSSX Meeting, Oct. 19 - 23, 2014 (San Francisco, California,
U.S.A.); Abstracts, p. 276 (P465).
- Svetlana M. Nabokina, Katsuhisa Inoue, Veedamali S. Subramanian, Judith E.
Valle, Hiroaki Yuasa, Hamid M. Said: Molecular identification and functional
characterization of the human colonic thiamine pyrophosphate transporter.
Digestive Disease Week 2014, May 4 - 6, 2014 (Chicago, Illinois, U.S.A.);
Gastroenterology, 146(S1), S-493 (Su1886).
- Hiroaki Yuasa, Mai Furumiya, Katsuhisa Inoue, Kinya Ohta, Yayoi Hayashi:
Transcriptional regulation of PCFT: roles of KLF4, HNF4a,
CDX2 and C/EBPa in its uniquely gradiented
expression profile in the small intestine. American Association of
Pharmaceutical Scientists, 2013 Annual Meeting, Nov. 10 - 14, 2013 (San
Antonio, Texas, U.S.A.); Abstract W4361.
- Takahiro Yamashiro, Kinya Ohta, Katsuhisa Inoue, Mai Furumiya, Yayoi
Hayashi, Hiroaki Yuasa: Kinetic evaluation of sustained inhibitory effect of
myricetin on folate transport by proton-coupled folate transporter. American
Association of Pharmaceutical Scientists, 2013 Annual Meeting, Nov. 10 - 14,
2013 (San Antonio, Texas, U.S.A.); Abstract M1136.
- Yuko Ito, Kinya Ohta, Takahiro Katano, Katsuhisa Inoue, Hiroaki Yuasa:
Functional characteristics of aquaporin 7 as a facilitative glycerol
carrier. American Association of Pharmaceutical Scientists, 2013 Annual
Meeting, Nov. 10 - 14, 2013 (San Antonio, Texas, U.S.A.); Abstract M1118.
- Erina Inaoka, Mai Furumiya, Katsuhisa Inoue, Chihiro Nishijima, Takahiro
Yamashiro, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa: Noncompetitive
inhibitory effect of myricetin on folate transport by proton-coupled folate
transporter. American Association of Pharmaceutical Scientists, 2013 Annual
Meeting, Nov. 10 - 14, 2013 (San Antonio, Texas, U.S.A.); Abstract M1117.
- Tomoya Yasujima, Kinya Ohta, Kastuhisa Inoue, Hiroaki Yuasa: A rapid assay
method for the assessment of the functionality of organic cation
transporters by using a fluorescent nuclear staining agent. International
Symposium on Past, Present and Future of Molecular Pharmacokinetics, Jan. 16
- 18, 2012 (Tokyo, Japan); Abstract P2-28.
- Rika Hayashi, Katsuhisa Inoue, Kinya Ohta, Hiroaki Yuasa: Molecular
identification of a novel prostaglandin E2 transporter. 17th NA ISSX
Meeting, Oct. 16 - 20, 2011 (Atlanta, Georgia, U.S.A.); Abstracts, p. 187
(P341).
- Hiroaki Yuasa, Masahiko Ohkubo, Kinya Ohta, Katsuhisa Inoue: Involvement
of sodium-coupled monocarboxylate transporter-like activity in nicotinate
uptake by brush border membrane vesicles from the rat small intestine. 17th
NA ISSX Meeting, Oct. 16 - 20, 2011 (Atlanta, Georgia, U.S.A.); Abstracts,
pp. 183 - 184 (P331).
- Chihiro Nishijima, Katsuhisa Inoue, Kinya Ohta, Hiroaki Yuasa:
Identification of a novel function of SNBT1 as a sodium-dependent urate
transporter. 17th NA ISSX Meeting, Oct. 16 - 20, 2011 (Atlanta, Georgia,
U.S.A.); Abstracts, p. 183 (P330).
- Hiroaki Yuasa, Chihiro Nishijima, Mai Hatakeyama, Yayoi Hayashi, Kinya
Ohta, Katsuhisa Inoue: Functional modulation of proton-coupled folate
transporter by flavonoids. International Symposium on BA/BE of Oral Drug
Products, Jun. 29 - Jul. 1, 2011 (Kobe, Japan); Abstracts, p. 400 (P-48).
- Hiroaki Yuasa, Chihiro Nishijima, Mai Hatakeyama, Yayoi Hayashi, Kinya
Ohta, Katsuhisa Inoue: Effects of flavonoids on proton-coupled folate
transporter. Pharmaceutical Sciences World Congress 2010 (4th), Nov. 14 -
18, 2010 (New Orleans, Louisiana, U.S.A.); AAPS J, 12(S2), Abstract T3404.
- Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki Yuasa: Characterization of the transport of DAPI by hOCT1 for its utilization for rapid uptake assays. Pharmaceutical Sciences World Congress 2010 (4th), Nov. 14 - 18, 2010 (New Orleans, Louisiana, U.S.A.); AAPS J, 12(S2), Abstract T3402.
- Masahiko Ohkubo, Kinya Ohta, Katsuhisa Inoue, Hiroaki Yuasa: Kinetic
analysis of nicotinate uptake in the rat small intestine. Pharmaceutical
Sciences World Congress 2010 (4th), Nov. 14 - 18, 2010 (New Orleans,
Louisiana, U.S.A.); AAPS J, 12(S2), Abstract T3382.
- Misato Sugiura, Katsuhisa Inoue, Yasuhiro Nakai, Naoki Abe, Kinya Ohta, Mai Hatakeyama, Yayoi Hayashi, Hiroaki Yuasa: Functional characteristics of human proton-coupled folate transporter/heme carrier protein 1 (hPCFT/HCP1) heterologously expressed in mammalian cells. Pan-Pacific International Partnership Conference on Pharmaceutical and Life Sciences (The 4th US-Japan Joint Conference), Feb. 22 - 23, 2008 (Nagoya, Japan); Abstracts, p. 53 (P25).
- Naoki Abe, Katsuhisa Inoue, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa: Characterization of methotrexate uptake by proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in HEK293 cells. 8th International ISSX Meeting, Oct. 9 - 12, 2007 (Sendai, Japan); Drug Metab. Rev., 39(S1), p. 276 (386).
- Yoshihiro Tomari, Kinya Ohta, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Carrier-mediated transport of doxycycline in the perfused rat small intestine. 8th International ISSX Meeting, Oct. 9 - 12, 2007 (Sendai, Japan); Drug Metab. Rev., 39(S1), p. 175 (246).
- Shunsuke Kamigaso, Yayoi Hayashi, Mai Hatakeyama, Katsuhisa Inoue, Hiroaki Yuasa: Characterization of carrier-mediated methotrexate transport in the rat small intestine in situ. 8th International ISSX Meeting, Oct. 9 - 12, 2007 (Sendai, Japan); Drug Metab. Rev., 39(S1), p. 174 (245).
- Mai Hatakeyama, Katsuhisa Inoue, Kinya Ohta, Yayoi Hayashi, Hiroaki Yuasa: Characterization of PCFT/HCP1-mediated transport of methotrexate in Caco-2 cells. World Conference on Drug Absorption, Transport and Delivery, 4th, Jun. 20 - 22, 2007 (Kanazawa, Japan); Abstracts, p. 84 (PO19).
- Nami Fujimoto, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Effect of glycerol-related compounds on carrier-mediated glycerol uptake in HCT-15 cells. World Conference on Drug Absorption, Transport and Delivery, 4th, Jun. 20 - 22, 2007 (Kanazawa, Japan); Abstracts, p. 83 (PO18).
- Kinya Ohta, Katsuhisa Inoue, Hiroaki Yuasa: Comparison of functional features between human MATE1 and MATE2-K, renal organic
cation/H+ antiporters. Pharmaceutical Sciences World Congress, Apr. 22 - 25, 2007 (Amsterdam, The Netherlands); Abstracts, DMT-T-023 (DMT-T-023).
- Munenori Ishimaru, Katsuhisa Inoue, Yasuhiro Nakai, Mai Hatakeyama, Yayoi Hayashi,
Hiroaki Yuasa: Functional characterization of human HCP1 as a proton-coupled folate transporter. Pharmaceutical Sciences World Congress, Apr. 22 - 25, 2007 (Amsterdam, The Netherlands); Abstracts, DMT-M-030 (DMT-M-030).
- Emiru Takeda, Yayoi Hayashi, Mai Hatakeyama, Kazuya Ooi, Ryuji Kato, Katsuhisa Inoue, Hiroaki Yuasa: Effect of Lactobacillus casei strain Shirota on gastrointestinal motility in rats. 13th NA
ISSX/20th JSSX Meeting, Oct. 23 - 27, 2005 (Maui, Hawaii, U.S.A.); Drug
Metab. Rev., 37(S2), p. 326 (598).
- Mika Tanabe, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Functional identification of
Niemann-Pick C1 like 1 (NPC1L1) as a cholesterol transporter. 13th NA ISSX/20th JSSX Meeting, Oct. 23 - 27, 2005 (Maui, Hawaii, U.S.A.); Drug
Metab. Rev., 37(S2), p. 192 (342).
- Wataru Takagi, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Carrier-mediated transport of riboflavin in the brush border membrane vesicles of the rat small intestine: analysis of the mechanism of inhibition by
tricyclic-type drugs. 13th NA ISSX/20th JSSX Meeting, Oct. 23 - 27, 2005 (Maui, Hawaii, U.S.A.); Drug
Metab. Rev., 37(S2), p. 190 (338).
- Megumi Takagi, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Riboflavin uptake by Na+-independent carrier-mediated transport in HaCaT cells. 13th NA
ISSX/20th JSSX Meeting, Oct. 23 - 27, 2005 (Maui, Hawaii, U.S.A.); Drug
Metab. Rev., 37(S2), pp. 189 - 190 (337).
- Shiho Nakamura, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Functional analysis of rat organic solute transporter
a/b (rOSTa/b). 13th NA
ISSX/20th JSSX Meeting, Oct. 23 - 27, 2005 (Maui, Hawaii, U.S.A.); Drug
Metab. Rev., 37(S2), pp. 171 - 172 (305).
- Nao Kosaki, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Carrier-mediated transport of tetracyclines in Caco-2 cells. 13th NA
ISSX/20th JSSX Meeting, Oct. 23 - 27, 2005 (Maui, Hawaii, U.S.A.); Drug
Metab. Rev., 37(S2), p. 60 (90).
- Yayoi Hayashi, Emiru Takeda, Katsuhisa Inoue, Hiroaki Yuasa, Kazuya Ooi, Ryuji Kato: Effect of Lactobacillus casei on gastrointestinal motility in rats. US-Japan Conference on Drug Development and Rational Drug Design, Jul. 31 - Aug. 3, 2005 (Los Angeles, California, U.S.A.); Abstracts, p. 5/Poster Abstract (P10).
- Kinya Ohta, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Involvement of Na+-dependent carrier-mediated transport in intestinal glycerol absorption. Retrometabolism Based Drug Design and Targeting Conference, 5th, May 8 - 11, 2005 (Hakone, Japan); Abstracts, p. 51 (Poster 20).
- Saeko Hayashi, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Glycerol uptake in the
sinusoidal membrane vesicles of the rat liver. Pharmaceutical Sciences
World Congress, May 30 - Jun. 3, 2004 (Kyoto, Japan); Abstracts, p. 145
(P2E-II-075).
- Takahiro Iwao, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa, Jun Watanabe: First-pass
metabolism of diltiazem in the perfused rat small intestine.
Pharmaceutical Sciences World Congress, May 30 - Jun. 3, 2004 (Kyoto,
Japan); Abstracts, p. 131 (P2E-II-018).
- Hiroaki Yuasa, Ken-ichiro Ohta, Yayoi Hayashi, Katsuhisa Inoue: Carrier-mediated riboflavin
uptake in the brush border membrane vesicles of the rat colon.
Pharmaceutical Sciences World Congress, May 30 - Jun. 3, 2004 (Kyoto,
Japan); Abstracts, p. 128 (P2E-II-007).
- Kinya Ohta, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Kinetic characterization of
carrier-mediated glycerol transport in the perfused rat small intestine.
Pharmaceutical Sciences World Congress, May 30 - Jun. 3, 2004 (Kyoto,
Japan); Abstracts, p. 128 (P2E-II-006).
- Yayoi Hayashi, Naomi Uchii, Ayako Ito, Hiroaki Yuasa: Salivary excretion of
zopiclone in rats. Pharmaceutical Sciences World Congress, May 30 - Jun. 3, 2004 (Kyoto, Japan); Abstracts, p. 125 (P1A-II-082).
- Tadaaki Suzuki, Takahiro Iwao, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa: Comparative
evaluation of diltiazem metabolism in enterocytes, S9 fraction and
microsomes from the rat small intestine. Pharmaceutical Sciences World
Congress, May 30 - Jun. 3, 2004 (Kyoto, Japan); Abstracts, p. 112
(P1A-II-031).
- Katsuhisa Inoue, You-Jun Fei, Lina Zhuang, Gopal Elangovan, Seiji Miyauchi, Vadivel Ganapathy: Molecular and functional characterization of mouse
NaCT, a
sodium-coupled citrate transporter. Pharmaceutical Sciences World
Congress, May 30 - Jun. 3, 2004 (Kyoto, Japan); Abstracts, p. 351
(P1E-VIII-007).
- Hiroaki Yuasa, Shigemitsu Tomei, Yayoi Hayashi, Katsuhisa Inoue: Riboflavin uptake in the
brush border membrane vesicles of the rat small intestine: transport
mechanism and effects of tricyclic-type drugs. International Congress of
FIP, 63rd (World Congress of Pharmacy and Pharmaceutical Sciences 2003),
Sept. 4 - 9, 2003 (Sydney, New South Wales, Australia); Abstracts, p. 53
(DDT-P-020).
- You-Jun Fei, Katsuhisa Inoue, Vadivel Ganapathy: Structural and functional
characteristics of two Na+-coupled
dicarboxylate transporters (ceNaDC1 and ceNaDC2) from Caenorhabditis
elegans and their relevance to life span. Expermental Biology 2003, Apr.
11 - 15, 2003 (San Diego, California, U.S.A.); (D486-332.21).
- You-Jun Fei, Katsuhisa Inoue, Vadivel Ganapathy: Cloning and functional
characterization of a Na+-coupled
transporter (ceINDY3) for dicarboxylates and tricarboxylates from
Caenorhabditis elegans. Expermental Biology 2003, Apr. 11 - 15, 2003 (San
Diego, California, U.S.A.); (D501-583.15).
- Takahiro Iwao, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa, Jun Watanabe: First-pass
metabolism of nifedipine in the rat small intestine. International
Congress on Molecular Biopharmaceutics, 1st, Jan. 22 - 24, 2003 (Honolulu,
Hawaii, U.S.A.); Abstracts, p. 92 (#191).
- Shigemitsu Tomei, Yayoi Hayashi, Katsuhisa Inoue, Hiroaki Yuasa, Jun Watanabe:
Carrier-mediated transport of riboflavin in the brush border membrane
vesicles of the rat intestine: effects of tricyclic-type drugs.
International Congress on Molecular Biopharmaceutics, 1st, Jan. 22 - 24,
2003 (Honolulu, Hawaii, U.S.A.); Abstracts, p. 91 (#190).
- Hiroaki Yuasa, Aki Nakajima, Katsuhisa Inoue, Yayoi Hayashi: Transport functions of
biotin carrier in the rat intestine: potential roles in drug absorption.
American Association of Pharmaceutical Scientists, 2002 Annual Meeting,
Nov. 10 - 14, 2002 (Toronto, Ontario, Canada); AAPS PharmSci., 4(4),
Abstract R6157 (R6157).
- Takatoshi Nakamura, Katsuhisa Inoue, Yayoi Hayashi, Hiroaki Yuasa, Jun Watanabe: Effects
of modified bovine serum albumins on the disposition of fractionated
heparin in rats: correlation between in vivo and in vitro. 61st
International Congress of FIP (World Congress of Pharmacy and
Pharmaceutical Sciences 2001), Sept. 1 - 6, 2001 (Singapore); Abstracts,
p. 65 (PDM-P-100).
- Hiroaki Yuasa, Shigemitsu Tomei, Katsuhisa Inoue, Yayoi Hayashi, Jun Watanabe: Transport
functions of the riboflavin carrier in the rat small intestine: potential
roles in drug absorption. US-Japan Conference on Drug Development and
Rational Drug Therapy, Aug. 6 - 8, 2001 (Hachioji, Japan); Proceedings, p.
97 (P-44).
- Shigemitsu Tomei, Hiroaki Yuasa, Katsuhisa Inoue, Yayoi Hayashi, Jun Watanabe: Potential
roles of riboflavin transporter in intestinal drug absorption. World
Conference on Drug Absorption and Drug Delivery, Jun. 18 - 20, 2001
(Copenhagen, Denmark); Abstracts, pp. 63 - 64 (II-48).
- Takatoshi Nakamura, Katsuhisa Inoue, Hiroaki Yuasa, Jun Watanbe: Effects of maleylated
bovine serum albumin (Mal-BSA) on the disposition of fractionated heparin
in rats . Millennial World Congress of Pharmaceutical Sciences, Apr. 16 -
20, 2000 (San Francisco, California, U.S.A.); Abstracts, p. 162 (1-10027).
- Kazuhito Nakamura, Yayoi Hayashi, Hiroaki Yuasa, Jun Watanbe: Effects of lithium
ingestion on salivary and renal excretion and tissue distribution of
lithium in rats . Millennial World Congress of Pharmaceutical Sciences,
Apr. 16 - 20, 2000 (San Francisco, California, U.S.A.); Abstracts, p. 161
(1-10025).
- Yayoi Hayashi, Yoshiko Minakuchi, Hiroaki Yuasa, Jun Watanbe: Salivary excretion
of cyclosporin in rats: potential involvement of P-glycoprotein.
Millennial World Congress of Pharmaceutical Sciences, Apr. 16 - 20, 2000
(San Francisco, California, U.S.A.); Abstracts, p. 161 (1-10024).
- Susumu Kume, Hiroaki Yuasa, Katsuhisa Inoue, Yayoi Hayashi, Jun Watanbe:
Site-dependent intestinal first-pass metabolism of amlodipine in rats.
Millennial World Congress of Pharmaceutical Sciences, Apr. 16 - 20, 2000
(San Francisco, California, U.S.A.); Abstracts, p. 151 (3-9012).
- Katsuhisa Inoue, Michitaka Tanaka, Hiroaki Yuasa, Jun Watanbe: First-pass metabolism of
nifedipine in serotonin-depleted rats. Millennial World Congress of
Pharmaceutical Sciences, Apr. 16 - 20, 2000 (San Francisco, California,
U.S.A.); Abstracts, p. 151 (3-9011).
- Eiji Hashimoto, Hiroaki Yuasa, Katsuhisa Inoue, Yayoi Hayashi, Jun Watanbe:
Site-dependent first-pass metabolism of diltiazem in the rat intestine.
Millennial World Congress of Pharmaceutical Sciences, Apr. 16 - 20, 2000
(San Francisco, California, U.S.A.); Abstracts, p. 150 (3-9006).
- Shigemitsu Tomei, Hiroaki Yuasa, Jun Watanbe: Effects of tricyclic-like drugs on
riboflavin transport in the rat small intestine. Millennial World Congress
of Pharmaceutical Sciences, Apr. 16 - 20, 2000 (San Francisco, California,
U.S.A.); Abstracts, p. 80 (1-3020).
- Miwa Hoshino, Naohide Hirashima, Katsuhisa Inoue, Hiroaki Yuasa, Mamoru Nakanishi, Jun Watanabe: Cloning of scavenger receptors responsible for uptake of
fractionated heparin in rat Kupffer cells. Millennial World Congress of
Pharmaceutical Sciences, Apr. 16 - 20, 2000 (San Francisco, California,
U.S.A.); Abstracts, p. 79 (1-3019).
- Hiroaki Yuasa, Mayumi Torimoto, Shigemitsu Tomei, Jun Watanbe: Carrier-mediated drug
transport in the colon: implications in designing drugs for sustained
release formulations. Millennial World Congress of Pharmaceutical
Sciences, Apr. 16 - 20, 2000 (San Francisco, California, U.S.A.);
Abstracts, p. 77 (1-3006).
- Hiroaki Yuasa, Shigemitsu Tomei, Jun Watanabe: Effects of phenothiazines on the
intestinal transport of riboflavin. International Conference on Drug
Interaction, Oct. 21 - 23, 1999 (Hamamatsu, Japan); Abstracts, p. 70
(P-024).
- Jun Watanabe, Hiroshi Itoh, Yayoi Hayashi, Hiroaki Yuasa: Effects of sodium
chloride on salivary excretion of lithium in rats. Lithium-Lexington
Symposium, May 7 - 11, 1999 (Lexington, Kentucky, U.S.A.).
- Hiroaki Yuasa, Shigemitsu Tomei, Mayumi Torimoto, Jun Watanabe: Carrier-mediated drug
transport in the rat colon. International Symposium on Strategies for
Optimizing Oral Drug Delivery: Scientific to Regulatory Approaches, Apr.
19 - 21, 1999 (Kobe, Japan); Abstracts, p. 120 (A-06).
- Yoko Nakasuji, Masami Haba, Hiroaki Yuasa, Jun Watanabe: Kinetic
characterization for release of fractionated [3H]heparin-derived
radioactivity by rat peritoneal macrophages. Japanese-American Conference
on Pharmacokinetics and Biopharmaceutics, 9th, Jul. 29 - 31, 1998 (Nagoya,
Japan); Abstracts, p. 78 (2-3).
- Makoto Ohta, Hiroaki Yuasa, Jun Watanabe: Intestinal transport of
monosaccharide-type permeability probes: carrier-mediated transport of D-xylose. Japanese-American Conference on Pharmacokinetics and
Biopharmaceutics, 9th, Jul. 29 - 31, 1998 (Nagoya, Japan); Abstracts, p.
63 (1-19).
- Hiroaki Yuasa, Makoto Ohta, Jun Watanabe: Intestinal transport of
monosaccharide-type permeability probes: comparison between D-xylose and
D-mannitol. Conference on Challenges for Drug Delivery and Pharmaceutical
Technology, Jun. 9 - 11, 1998 (Tokyo, Japan); Abstracts, p. 176 (P-2A-36).
- Jun Watanabe, Masami Haba, Norizumi Sawabu, Hiroaki Yuasa: Interaction of
fractionated heparin and organic anions in the uptake by rat liver
parenchymal cells. CRS-CPA Joint Workshop on Recent Advances in Drug
Delivery Sciences and Technology, Sept. 20 - 22, 1997 (Beijing, China).
- Jun Watanbe, Kensaku Yoshida, Yayoi Hayashi, Hiroaki Yuasa: In vitro - in vivo
correlation in intestinal lithium absorption in rats. South Africa Lithium
Symposium, Aug. 31 - Sept. 6, 1997 (Johannesburg, South Africa).
- Jun Watanbe, Masami Haba, Kimihiko Urano, Chihiro Tanaka, Hiroaki Yuasa: Kinetic
characterization of the uptake of fractionated heparin in rat liver
cultured parenchymal cells, isolated Kupffer cells and isolated peritoneal
macrophages. Symposium on the Impact of Pharmacokinetics in Modern Drug
Development, May 16 - 17, 1997 (San Francisco, California, U.S.A.).
- Kenji Matsuda, Hiroaki Yuasa, Jun Watanabe: Dose-dependent gastrointestinal
absorption of cefatrizine in rats in vivo. Japanese-American Conference on
Pharmacokinetics and Biopharmaceutics, 8th, Jul. 28 - 30, 1996 (Seattle,
Washington, U.S.A.); Abstracts, p. 62 (32).
- Kimihiko Urano, Masami Haba, Hiroaki Yuasa, Jun Watanabe: Involvement of
scavenger-like receptor in internalization of fractionated 3H-heparin
in rat parenchymal liver cells. Japanese-American Conference on
Pharmacokinetics and Biopharmaceutics, 8th, Jul. 28 - 30, 1996 (Seattle,
Washington, U.S.A.); Abstracts, p. 48 (18).
- Masami Haba, Hiroaki Yuasa, Jun Watanabe: Effect of plasma proteins on the
initial uptake of fractionated heparin in isolated rat Kupffer cells.
Japanese-American Conference on Pharmacokinetics and Biopharmaceutics,
8th, Jul. 28 - 30, 1996 (Seattle, Washington, U.S.A.); Abstracts, p. 47
(17).
- Hiroaki Yuasa, Yukie Kimura, Kaori Hamamoto, Jun Watanabe: Evaluation of large
intestine as an absorption site for colonic drug delivery. International
Symposium on Controlled Release of Bioactive Materials, 23rd, Jul. 7 - 10,
1996 (Kyoto, Japan); Proceedings, pp. 547 - 548 (4419).
- Yayoi Hayashi, Tetsuro Nakamura, Hiroaki Yuasa, Koji Suzuki, Jun Watanabe: Effects
of highly ion-selective ionophores on intestinal absorption of lithium in
rats. International Symposium on Controlled Release of Bioactive
Materials, 23rd, Jul. 7 - 10, 1996 (Kyoto, Japan); Proceedings, pp. 421 -
422 (4201).
- Jun Watanabe, Tetsurou Nakamura, Yayoi Hayashi, Hiroaki Yuasa, Norihide Yoshioka, Koji Suzuki: Inhibitory effects of ion-selective ionophores on intestinal
absorption of lithium in rats. Malta Lithium Symposium, Nov. 6 - 10, 1995
(St. Paul's Bay, Malta).
- Hiroaki Yuasa, Yukie Kimura, Chiaki Kuno, Jun Watanabe: Comparative assessment of
small and large intestinal membrane permeability in rats. International
Symposium on Controlled Release of Bioactive Materials, 22nd, Jul. 30 -
Aug. 2, 1995 (Seattle, Washington, U.S.A.); Proceedings, pp. 610 - 611
(3007).
- Jun Watanabe, Masami Haba, Konomu Sumiyoshi, Chihiro Tanaka, Hiroaki Yuasa: Comparison
of uptake characteristics of fractionated heparin among liver parenchymal
cells, Kupffer cells, and peritoneal macrophages of rats. International
Symposium on Controlled Release of Bioactive Materials, 22nd, Jul. 30 -
Aug. 2, 1995 (Seattle, Washington, U.S.A.); Proceedings, pp. 608 - 609
(3006).
- Yayoi Hayashi, Tetsuro Nakamura, Hiroaki Yuasa, Koji Suzuki, Jun Watanabe:
Inhibition of intestinal absorption of lithium by highly ion-selective
ionophores in rats. International Symposium on Controlled Release of
Bioactive Materials, 22nd, Jul. 30 - Aug. 2, 1995 (Seattle, Washington,
U.S.A.); Proceedings, pp. 606 - 607 (3005).
- Jun Watanabe, Meguru Achira, Kimihiko Urano, Masami Haba, Hiroaki Yuasa: Effect of a-globulin on the uptake of fractionated 3H-heparin in the perfused rat liver:
comparison between parenchymal and non-parenchymal cells.
Japanese-American Conference on Pharmacokinetics and Biopharmaceutics,
7th, Jul. 31 - Aug. 2, 1994 (Hiroshima, Japan); Abstracts, 2-28.
- Hiroaki Yuasa, Emiko Suzuki, Jun Watanabe: Estimation of in vivo intestinal
membrane permeability of 5-fluorouracil in rats. Japanese-American
Conference on Pharmacokinetics and Biopharmaceutics, 7th, Jul. 31 - Aug.
2, 1994 (Hiroshima, Japan); Abstracts, 2-12.
- Masami Haba, Jun Watanabe, Hiroaki Yuasa: Kinetic analysis of the uptake of
fractionated 3H-heparin in rat isolated
Kupffer cells. Japanese-American Conference on Pharmacokinetics and
Biopharmaceutics, 7th, Jul. 31 - Aug. 2, 1994 (Hiroshima, Japan);
Abstracts, 1-26.
- Hiroaki Yuasa, Wataru Numata, Koji Kawanishi, Jun Watanabe: Estimation of
intestinal membrane permeability in vivo in rats. American Association of
Pharmaceutical Scientists, 8th Annual Meeting, Nov. 14 - 18, 1993
(Orlando, Florida, U.S.A.); Pharm. Res., 10, S-418 (PPDM8478).
- Jun Watanabe, Konomu Sumiyoshi, Hiroya Muranishi, Hiroaki Yuasa: Slow release of
fractionated 3H-heparin from rat
parenchymal hepatocytes in primary culture. American Association of
Pharmaceutical Scientists, 8th Annual Meeting, Nov. 14 - 18, 1993
(Orlando, Florida, U.S.A.); Pharm. Res., 10, S-322 (PPDM8094).
- Masami Haba, Hiroya Muranishi, Hiroaki Yuasa, Jun Watanabe: Uptake of FITC-fractionated heparin by rat parenchymal hepatocytes in primary
culture. FIP, 53th, Sept. 6 - 10, 1993 (Tokyo, Japan).
- Jun Watanabe, Junya Higuchi, Yayoi Hayashi, Hiroaki Yuasa: Factors affecting
salivary and systemic clearances of lithium in dogs. U.K. Lithium
Symposium, 3rd, Sept. 6 - 9, 1992 (Wolverhampton, U.K.).
- Yayoi Hayashi, Jun Watanabe, Hiroaki Yuasa: Effects of bumetanide on the
salivary excretion of lithium in the perfused rat mandibular gland.
Japanese-American Conference on Pharmacokinetics and Biopharmaceutics,
6th, Aug. 2 - 4, 1992 (Buffalo, New York, U.S.A.); Abstracts, p. 38 (210).
- Jun Watanabe, Akira Yamazaki, Hiroaki Yuasa: Dose-dependent release of
fractionated 3H-heparin from rat liver
parenchymal cells. Japanese-American Conference on Pharmacokinetics and
Biopharmaceutics, 6th, Aug. 2 - 4, 1992 (Buffalo, New York, U.S.A.);
Abstracts, p. 37 (208).
- Hiroya Muranishi, Jun Watanabe, Hiroaki Yuasa: Effects of various inhibitors of
hepatic transport on initial uptake of fractionated 3H-heparin
by rat parenchymal hepatocytes in primary culture. Japanese-American
Conference on Pharmacokinetics and Biopharmaceutics, 6th, Aug. 2 - 4, 1992
(Buffalo, New York, U.S.A.); Abstracts, p. 26 (119).
- Hiroaki Yuasa, Michie Sekiya, Jun Watanabe: Gastric emptying-limited oral
absorption of a-linolenic acid administered as
MFGM (milk fat globule membrane) emulsion in rats. Japanese-American
Conference on Pharmacokinetics and Biopharmaceutics, 6th, Aug. 2 - 4, 1992
(Buffalo, New York, U.S.A.); Abstracts, p. 18 (104).
- Hiroaki Yuasa, Gordon L. Amidon, David Fleisher: Noncompetitive inhibition of
intestinal cephradine uptake by enalapril: an enalapril specific
inhibitory binding site on the peptide carrier. American Association of
Pharmaceutical Scientists, 6th Annual Meeting, Nov. 17 - 21, 1991
(Washington, D.C., U.S.A.); Pharm. Res., 8, S-221 (PDD7380).
- Hiroaki Yuasa, Gordon L. Amidon, David Fleisher: Kinetic characterization of
aminocephalosporin uptake in intestinal brush border membrane vesicles:
quantitative correlation of vesicle data to perfusion data. American
Association of Pharmaceutical Scientists, 6th Annual Meeting, Nov. 17 -
21, 1991 (Washington, D.C., U.S.A.); Pharm. Res., 8, S-198 (PDD7287).
- Hiroaki Yuasa, Tzyy-Show H. Chen, Gordon L. Amidon: Intestinal absorption of acid
and basic drugs: effect of concentration and surface pH on apparent
permeability. American Association of Pharmaceutical Scientists, 5th
Annual Meeting, Nov. 4 - 8, 1990 (Las Vegas, Nevada, U.S.A.); Pharm. Res.,
7, S-260 (PPDM8218).
- Hiroaki Yuasa, Gordon L. Amidon, David Fleisher: Cephradine uptake in intestinal
brush border membrane vesicles of rats and rabbits. Japanese-American
Conference on Pharmacokinetics and Biopharmaceutics, 5th, Jul. 16 - 18,
1990 (Tokyo, Japan); Abstracts, p. 107.
- Hiroaki Yuasa, Tatsuji Iga, Manabu Hanano, Jun Watanabe: Disposition of
3-O-methyl-D-glucose in the gastrointestinal tract following the
intragastric administration to rats. Japanese-American Conference on
Pharmacokinetics and Biopharmaceutics, 4th, Jul. 31 - Aug. 2, 1988 (San
Francisco, California, U.S.A.); Abstracts, p. 30 (8).
- Jun Watanabe, Naruaki Nomura, Keizo Kuwata, Hiroaki Yuasa, Shoji Ozeki: Uptake
capacity of liver and other tissues for fractionated 3H-heparin
in rat. Japanese-American Conference on Pharmacokinetics and
Biopharmaceutics, 4th, Jul. 31 - Aug. 2, 1988 (San Francisco, California,
U.S.A.); Abstracts, p. 30 (7).
- Hiroaki Yuasa, Tatsuji Iga, Manabu Hanano, Jun Watanabe: Estimation of resistance
of unstirred water layer to solute transport in intestinal perfusion
systems. Japanese-United States Congress of Pharmaceutical Sciences, Dec.
2 - 7, 1987 (Honolulu, Hawaii, U.S.A.); J. Pharm. Sci., 76, S105
(D07-W-84).
- Naruaki Nomura, Jun Watanabe, Hiroaki Yuasa, Shoji Ozeki: Disposition of
fractionated 3H-heparin following
repetitive intravenous administration to rats. Japanese-United States
Congress of Pharmaceutical Sciences, Dec. 2 - 7, 1987 (Honolulu, Hawaii,
U.S.A.); J. Pharm. Sci., 76, S88 (D07-W-15).
- Junya Higuchi, Jun Watanabe, Yayoi Hayashi, Hiroaki Yuasa, Shoji Ozeki: Effect of
stimulated salivation on lithium clearances in dogs under the condition of
water loading. Japanese-United States Congress of Pharmaceutical Sciences,
Dec. 2 - 7, 1987 (Honolulu, Hawaii, U.S.A.); J. Pharm. Sci., 76, S73
(D06-W-50).
2) Invited presentations
- Katsuhisa Inoue, Hiroaki Yuasa: Molecular mechanism of intestinal
nucleobase transport in mammals. International Symposium on Purine and
Pyrimidine Metabolism in Man, 14th, Feb. 18 - 21, 2011 (Tokyo, Japan);
Symposist.
- Hiroaki Yuasa: Evaluation and prediction of gastrointestinal drug absorption by physiological mechanism-based approach. US-Japan Conference on Drug Development and Rational Drug Design,
Jul. 31 - Aug. 3, 2005 (Los Angeles, California, U.S.A.); Abstracts, p. 8/Oral Abstract;
Symposist.
- Hiroaki Yuasa: Glycerol carriers as novel resources for drug delivery and drug development. Retrometabolism Based Drug Design and Targeting Conference, 5th, May 8 - 11, 2005 (Hakone, Japan);
Symposist.
- Hiroaki Yuasa: Evaluation and prediction methods of intestinal drug
absorption: implications in oral drug delivery. Conference on Frontiers of
Drug Development, Jul. 26 - 28, 1999 (Pasadena, California, U.S.A.);
Proceedings, p. 30; Symposist.
- Hiroaki Yuasa: A new development of in vivo gastrointestinal absorption
analysis for in vitro - in vivo correlation. Japanese-American Conference
on Pharmacokinetics and Biopharmaceutics, 8th, Jul. 28 - 31, 1996
(Seattle, Washington, U.S.A.); Abstracts, p. 21; Symposist.
3) Lectures
- Hiroaki Yuasa: Proton-coupled folate transporter: its characteristics of
function, expression and modulation by flavonoids. Oct. 27, 2014 (Laboratory
of Reproductive and Developmental Toxicology (Masahiko Negishi, Head,
Pharmacogenetics section), National Institutes of Environmental Health
Sciences, NIH, Research Triangle Park, North Carolina, U.S.A.).
- Hiroaki Yuasa: Proton-coupled folate transporter: its characteristics of
function, expression and modulation by flavonoids. Oct. 24, 2014 (College of
Pharmacy (Professor James T. Dalton), The University of Michigan, Ann Arbor,
Michigan, U.S.A.).
- Hiroaki Yuasa: Estimation of intestinal membrane permeability in vivo by the
analysis of gastrointestinal drug disposition: a new approach for
physiological modeling of oral drug absorption. Nov. 12, 1993 (College of
Pharmacy (Assistant Professor Patrick J. Sinko), Rutgers University,
Piscataway, New Jersey, U.S.A.).
- Hiroaki Yuasa: Estimation of intestinal membrane permeability in vivo by the
analysis of gastrointestinal drug disposition: a new approach for
physiological modeling of oral drug absorption. Jul. 23, 1993 (School of
Pharmacy (Professor Ronald T. Borchardt), The University of Kansas,
Lawrence, Kansas, U.S.A.).
- Hiroaki Yuasa: Estimation of intestinal membrane permeability in vivo by the
analysis of gastrointestinal drug disposition: a new approach for
physiological modeling of oral drug absorption. Jul. 21, 1993 (Department
of Pharmacy (Professor Leslie Z. Benet), University of California, San
Francisco, California, U.S.A.).
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