精密有機反応学分野|名古屋市立大学 大学院薬学研究科・薬学部

投稿論文

""New strategy for synthesis of bis-pocket metalloporphyrins enabling regioselective catalytic oxidation of alkanes"

Taisei Amano, Hideki Inagaki, Yoshinori Shirakawa, Yuuki Yano, Yosuke Hisamatsu, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi
Bull. Chem. Soc. Jpn. in press. doi:10.1246/bcsj.20210236.

""Structure-based identification of potent lysine-specific demethylase 1 inhibitor peptides and temporary cyclization to enhance proteolytic stability and cell growth-inhibitory activity"

Hiroki Kitagawa, Masaki Kikuchi, Shin Sato, Hisami Watanabe, Naoki Umezawa, Maiko Kato, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi
J. Med. Chem. 2021, 64(7), 3707-3719.

""Fluorescence response and self-assembly of a tweezer-type synthetic receptor triggered by complexation with heme and its catabolites"

Yosuke Hisamatsu, Koki Otani, Hiroshi Takase, Naoki Umezawa, Tsunehiko Higuchi
Chem. Eur. J. 2021, 27(21), 6489-6499.

""医薬分野におけるゴールド（金）の有用性と可能性"

米田 誠治, 樋口 恒彦
薬学雑誌、2021, 141(3), 303-304.

""Effects of structural isomers of spermine on the higher-order structure of DNA and gene expression"

Tomoki Kitagawa, Takashi Nishio, Yuko Yoshikawa, Naoki Umezawa, Tsunehiko Higuchi, Chwen-Yang Shew, Takahiro Kenmotsu, Kenichi Yoshikawa
Int. J. Mol. Sci. 2021, 22(5), 2355-2369.

2020年

投稿論文

""Chemoselective arylation of dialkyl diselenides and application to the synthesis of a ε-N,N,N-trimethyllysine derivative"

Ryuhei Takahashi, Kenta Sakamoto, Naoki Umezawa, Takashi Umehara, Jun-ichi Matsuo
Eur. J. Org. Chem. (2020), 2020(42), 6649-6652.

""Development of cell-penetration PG-surfactants and its application in external peptide delivery to cytosol"

Natsumi Sumito, Shuhei Koeda, Naoki Umezawa, Yasumichi Inoue, Shinya Tsukiji, Tsunehiko Higuchi, Toshihisa Mizuno
Bioconj. Chem. 2020, 31(3), 821-833.

2019年

投稿論文

""フォルダマーの魅力─設計・構造・機能─"

大庭 誠, 梅澤 直樹, 出水 庸介
薬学雑誌、2019, 139(4), 579-580.

""Specific effects of antitumor active norspermidine on the structure and function of DNA"

Takashi Nishio, Yuko Yoshikawa, Chwen-Yang Shew, Naoki Umezawa, Tsunehiko Higuchi, Kenichi Yoshikawa
Sci. Rep. 2019, 9, 1-12.

""Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst"

Shota Teramae, Akane Kito, Tomoteru Shingaki, Yu Hamaguchi, Yuuki Yano, Takamori Nakayama, Yuko Kobayashi, Nobuki Kato, Naoki Umezawa, Yosuke Hisamatsu, Tetsuo Nagano, Tsunehiko Higuchi
Chem. Commun., 2019, 55(58), 8378-8381. Chem. Commun.誌の Inside Front Cover に選定されました

""Repulsive/attractive interaction among compact DNA molecules as judged through laser trapping: difference between linear- and branched-chain polyamines"

Yusuke Kashiwagi, Takashi Nishio, Masatoshi Ichikawa, Chwen-Yang Shew, Naoki Umezawa, Tsunehiko Higuchi, Koichiro Sadakane, Yuko Yoshikawa, Kenichi Yoshikawa
Colloid Polym. Sci., 2019, 297(3), 397-407.

""Stable iron porphyrin intramolecularly coordinated by alcoholate anion: synthesis and evaluation of axial ligand effect of alcoholate on spectroscopy and catalytic activity"

Yoshinori Shirakawa, Yuuki Yano, Yuki Niwa, Kanako Inabe, Naoki Umezawa, Nobuki Kato, Yosuke Hisamatsu, Tsunehiko Higuchi
Inorg. Chem. 2019, 58(7), 4268-4274.

"" Effect of the o-acetamido group on pH-dependent light emission of a 3-hydroxyphenyl-substituted dioxetane luminophore"

Yosuke Hisamatsu, Takehiro Fukiage, Kojiro Honma, Andrii G. Balia, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi
Org. Lett. 2019, 21(5), 1258-1262.

""Design, Synthesis, and Anticancer Activity of Iridium(III) Complex-Peptide Hybrids that Contain Hydrophobic Acyl Groups at the N-terminus of the Peptide Units"

Kana Naito, Kenta Yokoi, Chandrasekar Balachandran, Yosuke Hisamatsu, Shin Aoki
J. Inorg. Biochem., 2019, 199, 110785.

""Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Complexes Formed by the Self-assembly of a Hydrophobic Bis(Zn2+-cyclen) Complex, Copper, and Barbital Units that are Functionalized with Amino Acids in a Two-Phase Solvent System"

Yuya Miyazawa, Akib Bin Rahman, Yutaka Saga, Hiroki Imafuku, Yosuke Hisamatsu, Shin Aoki
Micromachines, 2019, 10(7), 452.

2018年

投稿論文

"" Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues"

Naoki Umezawa, Kasumi Tsuji, Shin Sato, Masaki Kikuchi, Hisami Watanabe, Yuhei Horai, Masashi Yamaguchi, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi
RSC Adv. 2018, 8, 36895-36902.

""Potent antimalarial activity of two arenes linked with triamine designed to have multiple interactions with heme"

Yosuke Sakata, Kosuke Yabunaka, Yuko Kobayashi, Hirohisa Omiya,　Naoki Umezawa, Hye-Sook Kim, Yusuke Wataya, Yoshimi Tomita, Yosuke Hisamatsu, Nobuki Kato, Hirokazu Yagi, Tadashi Satoh, Koichi Kato, Haruto Ishikawa, Tsunehiko Higuchi
ACS Med. Chem. Lett. 2018, 9(10), 980-985.

""Bypassing the rate limiting oxygen activation of heme oxygenase by hydrogen sulfide"

Toshitaka, Matsui, Ryota Sugiyama, Kenta Sakanashi, Yoko Tamura, Masaki Iida, Yukari Nambu, Tsunehiko Higuchi, Makoto Suematsu, Masao Ikeda-Saito
J. Biol. Chem. 2018, 293(43), 16931-16939. http://www.jbc.org/content/293/43/16931.abstract.html http://www.jbc.org/content/293/43/16931.full.pdf

""Distinct modulation of group I ribozyme activity among stereoisomers of a synthetic pentamine with structural constraints"

Mst A Gulshan, Kasumi Tsuji, Shigeyoshi Matsumura, Tsunehiko Higuchi, Naoki Umezawa, Yoshiya Ikawa
Biochem. Biophys. Res. Commun. 2018, 504(4), 698-703.

""Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(III) protoporphyrin IX and its application as a supramolecular photosensitizer"

Yosuke Hisamatsu, Naoki Umezawa, Hirokazu Yagi, Koichi Kato, Tsunehiko Higuchi
Chem. Sci. 2018, 9(38), 7455-7467. Chem. Sci.誌の Inside Back Cover と HOT Article Collection に選定されました．

""A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model"

Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo
Nat. Commun. 2018, 9, 2688.

""Comparative study of polyethylene polyamines as activator molecules for a structurally unstable group I ribozyme"

Mst. Ara Gulshan, Shigeyoshi Matsumura, Tsunehiko Higuchi, Naoki Umezawa, Yoshiya Ikawa
Biosci. Biotechnol. Biochem., 2018, 82(8), 1404-1407.

""Branched-chain polyamine found in hyperthermophiles induces unique temperature-dependent structural changes in genome-size DNA"

Takashi Nishio, Yuko Yoshikawa, Wakao Fukuda, Naoki Umezawa, Tsunehiko Higuchi,Shinsuke Fujiwara, Tadayuki Imanaka, Kenichi Yoshikawa
ChemPhysChem, 2018, 19, 1-7.

""Biogenic triamine and tetraamine activate core catalytic ability of Tetrahymena group I ribozyme in the absence of its large activator module"

Mst Ara Gulshan, Md. Motiar Rahman, Shigeyoshi Matsumura, Tsunehiko Higuchi, Naoki Umezawa, Yoshiya Ikawa
Biochem. Biophys. Res. Commun., 2018, 496, 594-600.

""Design and Synthesis of a Luminescent Iridium Complex-Peptide Hybrid (IPH) that Detects Cancer Cells and Induces Their Apoptosis"

Abdullah-Al Masum, Kenta Yokoi, Yosuke Hisamatsu, Kana Naito, Babita Shashni, Shin Aoki
Bioorg. Med. Chem., 2018, 26(17), 4804-4816.

""Stereospecific synthesis of tris-heteroleptic tris-cyclometalated iridium(III) complexes via different heteroleptic halogen-bridged iridium(III) dimers and their photophysical properties"

Yuichi Tamura, Yosuke Hisamatsu, Ayami Kazama, Kenji Yoza, Kyouhei, Sato, Reiko Kuroda, Shin Aoki
Inorg. Chem., 2018, 57(8), 4571-4589.

""Luminescent iridium complex-peptide hybrids (IPHs) for therapeutics of cancer: design and synthesis of IPHs for detection of cancer cells and induction of their necrosis-type cell death"

Abdullah-Al Masum, Yosuke Hisamatsu, Kenta Yokoi, Shin Aoki
Bioinorg. Chem. Appl., 2018, Article ID 7578965, 18 pages.

2017年

投稿論文

""Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine"

Ryota Hidese, Ka Man Tse, Seigo Kimura, Eiichi Mizohata, Junso Fujita, Naoki Umezawa, Tsunehiko Higuchi, Tadayuki Imanaka, Tsuyoshi Inoue, Shinsuke Fujiwara
FEBS J., 2017, 284, 3684-3701.

"Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker"

Yuichi Amano, Naoki Umezawa, Shin Sato, Hisami Watanabe, Takashi Umehara, Tsunehiko Higuchi
Bioorg. Med. Chem., 2017, 25(3), 1227-1234

"Polyoxygenated seco-cyclohexenes and other constituents from Uvaria valderramensis"

Allan Patrick G. Macabeo, Peter Yuosef M. Rubio, Tsunehiko Higuchi, Naoki Umezawa, Christian Faderl, Simon Budde, Porferio S. Bangcaya
Biochemical Systematics and Ecology, 2017, 71, 200-204.

"Role of thiolate ligand in spin state and redox switching in the cytochrome P450 catalytic cycle"

Hiroshi Suzuki, Kanako Inabe, Yoshinori Shirakawa, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi
Inorg. Chem., 2017, 56(8), 4245-4248.

"Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1"

Yuichi Amano, Masaki Kikuchi, Shin Sato, Shigeyuki Yokoyama, Takashi Umehara, Naoki Umezawa, Tsunehiko Higuchi
Bioorg. Med. Chem., 2017, 25(9), 2617-2624.

"Design, synthesis, and anticancer activities of cyclometalated tris(2-phenylpyridine)iridium(III) complexes with cationic peptides at the 4'-position of the 2-phenylpyridine ligand"

Kenta, Yokoi, Yosuke Hisamatsu, Kana Naito, Shin Aoki
Eur. J. Inorg. Chem., 2017, 5295-5309.

"Design and synthesis of tris-Heteroleptic cyclometalated iridium(III) complexes consisting of three different nonsymmetric ligands based on ligand-selective electrophilic reactions via interligand HOMO hopping phenomena"

Yosuke Hisamatsu, Sarvendra Kumar, Shin Aoki
Inorg. Chem., 2017, 56(2), 886-899.

"Efficient synthesis of tris-heteroleptic iridium(III) complexes based on the Zn2+-promoted degradation of tris-Cyclometalated iridium(III) complexes and their photophysical properties"

Yuichi Tamura, Yosuke Hisamatsu, Sarvendra Kumar, Taiki Itoh, Kyouhei Sato, Reiko Kuroda, Shin Aoki
Inorg. Chem., 2017, 56(2), 812-833.

"Cationic amphiphilic tris-Cyclometalated iridium(III) complexes induce cancer cell death via interaction with Ca2+-calmodulin complex"

Yosuke Hisamatsu, Nozomi Suzuki, Abdullah-Al Masum, Ai Shibuya, Ryo Abe, Akira Sato, Sei-ichi Tanuma, Shin Aoki
Bioconjugate Chem., 2017, 28(2), 507-523.

2016年

投稿論文

"Design of new extraction surfactants for membrane proteins from peptide-gemini surfactants (PG-surfactants)"

Masahide Shibata, Shuhei Koeda, Tomoyasu Noji, Keisuke Kawakami, Yuya Ido, Yuichi Amano, Naoki Umezawa, Tsunehiko Higuchi, Takehisa Dewa, Shigeru Itoh, Nobuo Kamiya, and Toshihisa Mizuno
Bioconjugate Chem., 2016 27(10), 2469-2479

"Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA"

Akira Muramatsu, Yuta Shimizu, Yuko Yoshikawa, Wakao Fukuda, Naoki Umezawa, Yuhei Horai, Tsunehiko Higuchi, Shinsuke Fujiwara, Tadayuki Imanaka, Kenichi Yoshikawa
J. Chem. Phys., 145, 235103 (2016); doi: 10.1063/1.4972066

著作

"クライトン「生物無機化学」"

塩谷光彦 監訳
東京化学同人　21章 金属と神経変性疾患

2015年

投稿論文

"Efficient oxidation of ethers with pyridine N-oxide catalyzed by ruthenium porphyrins"

Nobuki Kato, Yu Hamaguchi, Naoki Umezawa and Tsunehiko Higuchi*
J. Porphyrins Phthalocyanines, 2015, 19(1-3), 411.

"Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA"

Naoki Umezawa, Yuhei Horai, Yuki Imamura, Makoto Kawakubo, Mariko Nakahira, Nobuki Kato, Akira Muramatsu, Yuko Yoshikawa, Kenichi Yoshikawa, Tsunehiko Higuchi
ChemBioChem. 2015 16(12), 1811-9

"環状化を用いたペプチド機能の光制御"

梅澤直樹、樋口恒彦
生体の科学 2015, 66(2), 102-107.

新聞記事

"血色素ヘムから広がる化学・創薬"

樋口恒彦
中部経済新聞　2015年3月17日

 

2014年

投稿論文

"Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles"

Kazuma Okada, Ryota Hidese, Wakao Fukuda, Masaru Niitsu, Koichi Takao, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Tairo Oshima, Yuko Yoshikawa, Tadayuki Imanaka, Shinsuke Fujiwara
J. Bacteriol., 2014, 196(10), 1866-1876.

 

2013年

投稿論文

"Effect of Helical Conformation and Side-Chain Structure on γ-Secretase Inhibition by β-Peptide Foldamers: Insight into Substrate Recognition"

Yuki Imamura, Naoki Umezawa, Satoko Osawa, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, Tsunehiko Higuchi
J. Med. Chem., 2013, 56(4), 1443-1454.

"Effective Chiral Discrimination of Tetravalent Polyamines on Single-DNA Compaction"

Yuko Yoshikawa, Naoki Umezawa, Yuki Imamura, Toshio Kanbe, Nobuki Kato, Kenichi Yoshikawa, Tadayuki Imanaka, Tsunehiko Higuchi
Angew. Chem. Int. Ed., 2013, 52(13), 3712-3716

"Synthesis of the Carbon Framework of Scholarisine A by Intramolecular Oxidative Coupling"

Tsugunori Watanabe, Nobuki Kato, Naoki Umezawa, Tsunehiko Higuchi
Chem. Eur. J., 2013, 19(13), 4255-4261

"Manganese Salen Complexes with Acid-Base Catalytic Auxiliary: Functional Mimetics of Catalase"

Yukinobu Noritake, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi
Inorg. Chem., 2013, 52(7), 3653-3662

"Nitrous Oxide Reduction-Coupled Alkene-Alkene Coupling Catalysed by Metalloporphyrin"

Shunsuke Saito, Hiro Ohtake, Naoki Umezawa, Yuko Kobayashi, Nobuki Kato, Masaaki Hirobe, Tsunehiko Higuchi
Chem. Commun., 2013, 49, 8979-8981

"ヘムから拡がる化学：黎明期からのヘム酵素モデル研究"

樋口恒彦
化学と工業 2013, 66(11), 919-921

 

2012年

投稿論文

"シトクロムP450の酸化活性種が解明"

樋口恒彦
化学 2012, 67(1), 70-71

 

2011年

投稿論文

"Photocontrol of Peptide Function: Backbone Cyclization Strategy with Photocleavable Amino Acid"

Naoki Umezawa, Yuka Noro, Kazuhiro Ukai, Nobuki Kato, Tsunehiko Higuchi
ChemBioChem, 2011, 12(11), 1694-1698.

 

2010年

投稿論文

"Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1"

Shinya Mimasu, Naoki Umezawa, Shin Sato, Tsunehiko Higuchi, Takashi Umehara, and Shigeyuki Yokoyama
Biochemistry, 49(30), 6494-6503 (2010)

"Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase"

Naoki Umezawa, Nobuyoshi Matsumoto, Shinsuke Iwama, Nobuki Kato and Tsunehiko Higuchi
Bioorg. Med. Chem., 18(17), 6340-6350 (2010)

2009年

投稿論文

"Turn-on fluorescent probe with visible light excitation for labeling of hexahistidine tagged protein"

Mie Kamoto, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Bioorg. Med. Chem. Lett., 19(8), 2285-2288 (2009)

"Inhibition of γ-Secretase Activity by Helical β-Peptide Foldamers"

Yuki Imamura, Naoto Watanabe, Naoki Umezawa, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, and Tsunehiko Higuchi
J. Am. Chem. Soc., 131(21), 7353-7359 (2009)

"Spectroscopic and Mechanistic Studies on Oxidation Reactions Catalyzed by the Functional Model SR Complex for Cytochrome P450: Influence of Oxidant, Substrate, and Solvent"

Natalya Hessenauer-Ilicheva, Alicja Franke, Maria Wolak, Tsunehiko Higuchi,* and Rudi van Eldik*
Chem. Eur. J. 15(45), 12447-12459 (2009)

"触媒機能におけるシトクロムP450配位構造の必然性：モデル錯体からのアプローチ"

樋口恒彦
有機合成化学協会誌, 67(2), 134-142 (2009)

2008年

投稿論文

"Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin: relevance to prostaglandin H2 isomerase catalysis"

Takehiro Yamane, Kohei Makino, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Angew. Chem. Int. Ed., 47(34), 6438-6440 (2008)

"Novel Probes Showing Specific Fluorescence Enhancement on Binding to Hexahistidine Tag"

Mie Kamoto, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Chem.-Eur. J., 14(26), 8004-8012 (2008)

"Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction"

Shoji Akita, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Bioorg. Med. Chem., 16(16), 7788-7794 (2008)

"Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore"

Kentaro Iso, Masayuki Inoue, Nobuki Kato, and Masahiro Hirama
Chem. Asian J. 3(2), 447-453 (2008)

"Synthesis of Staudinger-type Molecular Probe for Catch-and-release Purification of the Binding Protein for Potassium Isolespedezate, a Leaf-closing Substance of Leguminous Plant"

Tomohiko Fujii, Nobuki Kato, Izumi Iwakura, Yoshiyuki Manabe, and Minoru Ueda
Chem. Lett. 37(1), 52-53 (2008)

2007年

投稿論文

"(α/β+α)-Peptide antagonists of BH3 domain/Bcl-xL recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions"

Jack. D. Sadowsky, W. Douglas Fairlie, Erik B. Hadley, Hee-Seung Lee, Naoki Umezawa, Zaneta Nikolovska-Coleska, Shaomeng Wang, David C. S. Huang, York Tomita and Samuel H. Gellman
J. Am. Chem. Soc. 129(1), 139-154 (2007)

"A Versatile Strategy for the Synthesis of Crown Ether-Bearing Heterocycles: Discovery of Calcium-Selective Fluoroionophore"

Yuko Aoki, Naoki Umezawa, Yuko Asano, Keiichiro Hatano, Yuki Yano, Nobuki Kato, Tsunehiko Higuchi
Bioorg. Med. Chem. 15(22), 7108-7115 (2007)

A simple and versatile synthesis of crown ether-bearing heterocycles was achieved. Among the molecules synthesized, we found a Ca2+-selective fluoroionophore.

"化学進化的合成化学 ー 複数官能基の共同効果を利用した機能分子の動的創製"

樋口恒彦
ファルマシア, 43(8), 781-783 (2007)

"キナーゼ活性の蛍光検出"

梅澤直樹、樋口恒彦
蛋白質 核酸 酵素 （増刊：ケミカルバイオロジー）、52(13)、1601-1607 (2007)

"アミノ酸、ペプチドの化学的性質を利用した生体高分子の選択的認識と検出"

梅澤直樹、秋田昌二、鴨東美絵、樋口恒彦
薬学雑誌, 127(12), 1915-1925 (2007)

"Enantio-differential Approach using fluorescence-labeled Phyllanthurinolactone, a leaf-closing Factor of Phyllanthus urinaria L."

Nobuki Kato, Masayoshi Inada, Hirotaka Sato, Satoko Ito, Mitsuru Shoji, and Minoru Ueda
Tetrahedron Lett. 48(43), 7702-7705 (2007)

新聞記事

"塗料にDNA 車を特定"

樋口恒彦
日本経済新聞　2007年3月23日

2006年

投稿論文

"Design, Synthesis and Evaluation of New Type of L-Amino Acids Containing Pyridine Moiety as Nitric Oxide Synthase Inhibitor"

Ryosuke Ijuin, Naoki Umezawa and Tsunehiko Higuchi
Bioorg. Med. Chem., 14(10), 3563-3570 (2006)

We designed and synthesized a new class of nitric oxide synthase (NOS) inhibitors incorporating a picolyl group at the sulfur atom of cysteine, and evaluated their structure-activity relationship.

"Enhanced Catalase-like Activity of Manganese Salen Complexes in Water: Effect of Three-dimensionally Fixed Auxiliary"

Yoritada Watanabe, Azusa Namba, Naoki Umezawa, Masatoshi Kawahata, Kentaro Yamaguchi and Tsunehiko Higuchi
Chem. Commun. , (47), 4958-4960 (2006)

A new Mn(Salen) complex bearing an ureido group as an auxiliary that is three-dimensionally fixed by a cyclo-pentane ring fused to the Salen exhibited considerably higher catalase-like activity than the original Mn(Salen).

"Assembly State of Catalytic Modules as Chiral Switches in Asymmetric Strecker Amino Acid Synthesis"

Nobuki Kato, Tsuyoshi Mita, Motomu Kanai, Bruno Therrien, Masaki Kawano, Kentaro Yamaguchi, Hiroshi Danjo, Yoshihisa Sei, Akihiro Sato, Sanae Furusho, Masakatsu Shibasaki
J. Am. Chem. Soc. , 128(21), 6768-6769 (2006)

"Fluorescence Study on the Nyctinasty of Phyllanthus urinaria L. Using Novel Fluorescence-labeled Probe Compounds"

Nobuki Kato, Masayoshi Inada, Hirotaka Sato, Ryoji Miyatake, Tsutomu Kumagai, Minoru Ueda
Tetrahedron, 62(31), 7307-7318 (2006)

"機能性分子プローブを用いた植物就眠運動の生物有機化学-標的細胞と受容体タンパク質、そして鍵酵素-"

上田実、藤井智彦、加藤英介、杉本貴謙、加藤信樹
有機合成化学協会誌 64(2), 117-129 (2006)

2005年

投稿論文

"Unique Oxidation Reaction of Amides with Pyridine-N-oxide Catalyzed by Ruthenium Porphyrin - Direct Oxidative Conversion of N-Acyl-L-prolines to N-Acyl-L-glutamates"

Rina Ito, Naoki Umezawa and Tsunehiko Higuchi
J. Am. Chem. Soc., 127(3), 834-835 (2005)

"Mechanistic Studies on the Binding of Nitric Oxide to a Synthetic Heme-thiolate Complex Relevant to Cytochrome P450"

A. Franke, G. Stochel, N. Suzuki, T. Higuchi, K. Okuzono and R. van Eldik
J. Am. Chem. Soc., 127(15), 5360-5375 (2005)

"Evaluation of 3-Substituted Arginine Analogs as Selective Inhibitors of Human Nitric Oxide Synthase Isozymes"

Ryosuke Ijuin, Naoki Umezawa, Shin-ichi Nagai and Tsunehiko Higuchi
Bioorg. Med. Chem. Lett., 15(11), 2881-2885 (2005)

"On-Bead Fluorescence Assay for Serine/Threonine Kinases"

Shoji Akita, Naoki Umezawa and Tsunehiko Higuchi
Org. Lett., 7(25), 5565-5568 (2005)

"Organization of Supramolecular Assemblies of Fullerene, Porphyrin and Fluorescein Dye Derivatives on TiO2 Nanoparticles for Light Energy Conversion"

Taku Hasobe, Shigeki Hattori, Prashant V. Kamat, Yasuteru Urano, Naoki Umezawa, Tetsuo Nagano and Shunichi Fukuzumi
Chemical Physics, 319(1-3), 243-252 (2005)

"Chimeric (α/β+α)-Peptide Ligands for the BH3-Recognition Cleft of Bcl-xL: Critical Role of the Molecular Scaffold in Protein Surface Recognition"

Jack D. Sadowsky, Margaret A. Schmitt, Hee-Seung Lee, Naoki Umezawa, Shaomeng Wang, York Tomita and Samuel H. Gellman
J. Am. Chem. Soc., 127(34), 11966-11968 (2005)

"モデル分子を用いた一酸化窒素合成酵素の調節機能研究"

樋口恒彦
化学と教育, 53, 136-139 (2005)

"Direct Observation of a Target Cell of the Leaf-closing Factor by Using Novel Fluorescence-labeled Phyllanthurinolactone"

Hirotaka Sato, Masayoshi Inada, Takanori Sugimoto, Nobuki Kato, and Minoru Ueda
Tetrahedron Lett. 46(33), 5537-5541 (2005)

"Catalytic Enantioselective Synthesis of Key Intermediates for Triazol Antifungal Agents"

Masato Suzuki, Nobuki Kato, Motomu Kanai, and Masakatsu Shibasaki
Org. Lett. 7(13), 2527-2530 (2005)

"Recent progress in Lewis acid-Lewis base bifunctional asymmetic catalysis"

Motomu Kanai, Nobuki Kato, Ichikawa, E. and Masakatsu Shibasaki
Pure Appl. Chem. 77(12), 2047-2052 (2005)

"Power of Cooperativity: Lewis Acid-Lewis Base Bifunctional Asymmetric Catalysis"

Motomu Kanai, Nobuki Kato, Eiko Ichikawa, and Masakatsu Shibasaki
Synlett (10), 1491-1508 (2005)

研究活動

• 研究概要
• 研究・技術ジャーナル
• 業績集
• ライブラリー

• ｜ サイトポリシー
• ｜ サイトマップ

名古屋市立大学 大学院薬学研究科 創薬生命科学専攻 精密有機反応学分野
〒467-8603  名古屋市瑞穂区田辺通3-1    TEL/FAX:052-836-3435

All text and graphics at this site are copyright 2003-2018. All rights reserved.