Bioorganic-inorganic Chemistry

Archives

  • 2013
  • 2012
  • 2011
  • ~2010

2013

"Effect of Helical Conformation and Side-Chain Structure on γ-Secretase Inhibition by β-Peptide Foldamers: Insight into Substrate Recognition"
Yuki Imamura, Naoki Umezawa, Satoko Osawa, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, Tsunehiko Higuchi
J. Med. Chem. in press
"Effective Chiral Discrimination of Tetravalent Polyamines on Single-DNA Compaction"
Yuko Yoshikawa, Naoki Umezawa, Yuki Imamura, Toshio Kanbe, Nobuki Kato, Kenichi Yoshikawa, Tadayuki Imanaka, Tsunehiko Higuchi
Angew. Chem. Int. Ed. in press

 

2012

 

 

2011

"Photocontrol of Peptide Function: Backbone Cyclization Strategy with Photocleavable Amino Acid"
Naoki Umezawa, Yuka Noro, Kazuhiro Ukai, Nobuki Kato, Tsunehiko Higuchi
ChemBioChem 2011, 12(11), 1694-1698.

 

2010

"Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1"
Shinya Mimasu, Naoki Umezawa, Shin Sato, Tsunehiko Higuchi, Takashi Umehara, and Shigeyuki Yokoyama
Biochemistry, 49(30), 6494-6503 (2010)
"Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase"
Naoki Umezawa, Nobuyoshi Matsumoto, Shinsuke Iwama, Nobuki Kato and Tsunehiko Higuchi
Bioorg. Med. Chem., 18(17), 6340-6350 (2010)

2009

"Turn-on fluorescent probe with visible light excitation for labeling of hexahistidine tagged protein"
Mie Kamoto, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Bioorg. Med. Chem. Lett., 19(8), 2285-2288 (2009)
"Inhibition of γ-Secretase Activity by Helical β-Peptide Foldamers"
Yuki Imamura, Naoto Watanabe, Naoki Umezawa, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, and Tsunehiko Higuchi
J. Am. Chem. Soc., 131(21), 7353-7359 (2009)
"Spectroscopic and Mechanistic Studies on Oxidation Reactions Catalyzed by the Functional Model SR Complex for Cytochrome P450: Influence of Oxidant, Substrate, and Solvent"
Natalya Hessenauer-Ilicheva, Alicja Franke, Maria Wolak, Tsunehiko Higuchi,* and Rudi van Eldik*
Chem. Eur. J. 15(45), 12447-12459 (2009)

2008

"Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin: relevance to prostaglandin H2 isomerase catalysis"
Takehiro Yamane, Kohei Makino, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Angew. Chem. Int. Ed., 47(34), 6438-6440 (2008)
"Novel Probes Showing Specific Fluorescence Enhancement on Binding to Hexahistidine Tag"
Mie Kamoto, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Chem.-Eur. J., 14(26), 8004-8012 (2008)
"Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction"
Shoji Akita, Naoki Umezawa, Nobuki Kato, and Tsunehiko Higuchi
Bioorg. Med. Chem., 16(16), 7788-7794 (2008)
"Synthesis of the Bicyclo[7.3.0]dodecadiyne Core of the Maduropeptin Chromophore"
Kentaro Iso, Masayuki Inoue, Nobuki Kato, and Masahiro Hirama
Chem. Asian J. 3(2), 447-453 (2008)
"Synthesis of Staudinger-type Molecular Probe for Catch-and-release Purification of the Binding Protein for Potassium Isolespedezate, a Leaf-closing Substance of Leguminous Plant"
Tomohiko Fujii, Nobuki Kato, Izumi Iwakura, Yoshiyuki Manabe, and Minoru Ueda
Chem. Lett. 37(1), 52-53 (2008)

2007

"(α/β+α)-Peptide antagonists of BH3 domain/Bcl-xL recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions"
Jack. D. Sadowsky, W. Douglas Fairlie, Erik B. Hadley, Hee-Seung Lee, Naoki Umezawa, Zaneta Nikolovska-Coleska, Shaomeng Wang, David C. S. Huang, York Tomita and Samuel H. Gellman
J. Am. Chem. Soc. 129(1), 139-154 (2007)
"A Versatile Strategy for the Synthesis of Crown Ether-Bearing Heterocycles: Discovery of Calcium-Selective Fluoroionophore"
Yuko Aoki, Naoki Umezawa, Yuko Asano, Keiichiro Hatano, Yuki Yano, Nobuki Kato, Tsunehiko Higuchi
Bioorg. Med. Chem. 15(22), 7108-7115 (2007)
A Versatile Strategy for the Synthesis of Crown Ether-Bearing Heterocycles: Discovery of Calcium-Selective Fluoroionophore
A simple and versatile synthesis of crown ether-bearing heterocycles was achieved. Among the molecules synthesized, we found a Ca2+-selective fluoroionophore.
"Enantio-differential Approach using fluorescence-labeled Phyllanthurinolactone, a leaf-closing Factor of Phyllanthus urinaria L."
Nobuki Kato, Masayoshi Inada, Hirotaka Sato, Satoko Ito, Mitsuru Shoji, and Minoru Ueda
Tetrahedron Lett. 48(43), 7702-7705 (2007)

2006

"Design, Synthesis and Evaluation of New Type of L-Amino Acids Containing Pyridine Moiety as Nitric Oxide Synthase Inhibitor"
Ryosuke Ijuin, Naoki Umezawa and Tsunehiko Higuchi
Bioorg. Med. Chem., 14(10), 3563-3570 (2006)
Design, Synthesis and Evaluation of New Type of L-Amino Acids Containing Pyridine Moiety as Nitric Oxide Synthase Inhibitor
We designed and synthesized a new class of nitric oxide synthase (NOS) inhibitors incorporating a picolyl group at the sulfur atom of cysteine, and evaluated their structure-activity relationship.
"Enhanced Catalase-like Activity of Manganese Salen Complexes in Water: Effect of Three-dimensionally Fixed Auxiliary"
Yoritada Watanabe, Azusa Namba, Naoki Umezawa, Masatoshi Kawahata, Kentaro Yamaguchi and Tsunehiko Higuchi
Chem. Commun. , (47), 4958-4960 (2006)
Enhanced Catalase-like Activity of Manganese Salen Complexes in Water: Effect of Three-dimensionally Fixed Auxiliary
A new Mn(Salen) complex bearing an ureido group as an auxiliary that is three-dimensionally fixed by a cyclo-pentane ring fused to the Salen exhibited considerably higher catalase-like activity than the original Mn(Salen).
"Assembly State of Catalytic Modules as Chiral Switches in Asymmetric Strecker Amino Acid Synthesis"
Nobuki Kato, Tsuyoshi Mita, Motomu Kanai, Bruno Therrien, Masaki Kawano, Kentaro Yamaguchi, Hiroshi Danjo, Yoshihisa Sei, Akihiro Sato, Sanae Furusho, Masakatsu Shibasaki
J. Am. Chem. Soc. , 128(21), 6768-6769 (2006)
"Fluorescence Study on the Nyctinasty of Phyllanthus urinaria L. Using Novel Fluorescence-labeled Probe Compounds"
Nobuki Kato, Masayoshi Inada, Hirotaka Sato, Ryoji Miyatake, Tsutomu Kumagai, Minoru Ueda
Tetrahedron, 62(31), 7307-7318 (2006)

Bioorganic-inorganic Chemistry


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