2015
Keiichi Taniguchi, Yuuji Miyatake, Daisuke Hayashi, Atsuro Takami, Saotomo
Itoh, Saburo Yamamoto, Shigeaki Hida, Kikuo Onozaki, and Takemasa Takii.
Early-shared Mycobacterium bovis bacillus Calmette Guérin (BCG) sub-strains
effectively induce Th1 cytokine production in vivo
Microbiology and Immunology 2015 in press
2013
Keiichi Taniguchi, Takemasa Takii, Saburo Yamamoto, Jun-ichi Maeyama, Sumiko
Iho, Mitsuo Maruyama, Narushi Iizuka, Yuriko Ozeki, Sohkichi Matsumoto,
Tomohiro Hasegawa, Yuuji Miyatake, Saotomo Itoh and Kikuo Onozaki
Reactivation of immune responses against Mycobacterium tuberculosis by
boosting with the CpG oligomer in aged mice primarily vaccinated with Mycobacterium
bovis BCG
Immunity & Ageing 2013 in press
Itoh S, Yokoyama R, Kamoshida G, Fujiwara T, Okada H, Takii T, Tsuji T, Fujii S, Hashizume H, Onozaki K.
Staphylococcal superantigen-like protein 10 (SSL10) inhibits blood coagulation by binding to prothrombin and factor Xa via their γ-carboxyglutamic acid (Gla) domain.
J Biol Chem. 2013 in press
「黄色ブドウ球菌の分泌毒素SSL10がプロトロンビンなどビタミンK依存性血液凝固因子に結合し，血液凝固を抑制することを見出しました」
Fujiwara, N., Porcelli, S.A., Naka, T., Yano, I., Maeda, S., Kuwata, H., Akira, S., Uematsu, S., Takii, T. , Ogura, H., and K. Kobayashi Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance.
Biochim Biophys Acta. 1831(6):1177-1184 (2013）
Miki Adachi , Shosuke Okamoto , Satomi Chujyo , Tomohiro Arakawa , Megumi Yokoyama , Kyohei Yamada , Aki Hayashi, Kunihiko Akita , Masafumi Takeno , Saotomo Itoh , Takemasa Takii , Yuko Waguri-Nagaya , Takanobu Otsuka , Kazuichi Hayakawa , Keiji Miyazawa and Kikuo Onozaki
Cigarette smoke condensate extracts induce IL-1 beta production from rheumatoid
arthritis patient-derived synoviocytes, but not osteoarthritis patient-derived
synoviocytes, through aryl hydrocarbon receptor-dependent NF-kappa B activation
and novel NF-kappa B sites
Journal of Interferon & Cytokine Research 2013 in press
Saotomo Itoh, Natsuko Yamaoka, Go Kamoshida, Takemasa Takii, Tsutomu Tsuji, Hidetoshi Hayashi,Kikuo Onozaki
Staphylococcal superantigen-like protein 8 (SSL8) binds to tenascin C and
inhibits tenascin C - fibronectin interaction and cell motility of keratinocytes
Biochemical and Biophysical Research Communications (in press)
「黄色ブドウ球菌分泌毒素SSL8が細胞外マトリクスタンパク質テネイシンCに結合し，テネイシンとフィブロネクチンの相互作用を抑制すること，ケラチノサイトの運動を阻害することを見出しました」
2012
Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato
Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, Onozaki
K.
Antitubercular Activity of Disulfiram, an Antialcoholism Drug, against
Multidrug- and Extensively Drug-Resistant Mycobacterium tuberculosis Isolates.
Antimicrob Agents Chemother. 2012 Aug;56(8):4140-5
「抗酒癖薬ジスルフィラム（DSF)は多剤耐性結核菌の臨床分離株にに対してin vitroで抗菌活性を示した。結核菌感染モデルマウスにおいてもDSFを経口投与することにより臓器内の結核菌数を減少させた。DSFは投与後に血液中 で速やかにDDCに代謝され、DDCがin vivoでの活性本体であることを示した。」
Ryosuke Yokoyama, Saotomo Itoh, Go Kamoshida, Takemasa Takii, Satoshi Fujii,
Tsutomu Tsuji and Kikuo Onozaki
Staphylococcal superantigen-like protein 3 binds to toll like receptor
2 extracellular domain and inhibits cytokine production induced by S. aureus,
cell wall component or lipopeptides in murine macrophages
Infection and Immunity 2012 80(8):2816-2825
「黄色ブドウ球菌分泌毒素SSL3はToll like receptor 2(TLR2）の細胞外領域に結合し，黄色ブドウ球菌死菌やリポペプチドなどTLR2リガンドによるマクロファージからの炎症性サイトカイン産生を抑制することを見出しました」
Saotomo Itoh, Ryosuke Yokoyama, ChizukoMurase, Takemasa Takii, Tsutomu
Tsuji and Kikuo Onozaki
Staphylococcal superantigen-like protein 10 (SSL10) binds to phosphatidylserine
and apoptotic cells
Microbiology and Immunology 2012 56(6):363-371
「黄色ブドウ球菌分泌毒素SSL10はフォスファチジルセリンに結合し，アポトーシス細胞にカルシウムカルシウム非依存的に結合することを見出しました」
2011
「ＢＣＧ －Vaccine and Adjuvant －」 編集 瀧井猛将、前山順一、山本三郎 出版 結核予防会
ＩＳＢＮ ９７８－４－８７４５１－２７０－８ 平成２３年９月出版 【表紙へのリンク】
第４章 In vitro characteristics of BCG vaccine substrains 著 林 大介、瀧井猛将
Ozeki Y, Hirayama Y, Takii T, Yamamoto S, Kobayashi K, Matsumoto S
Loss of anti-mycobacterial efficacy in mice over time following vaccination
with Mycobacterium bovis bacillus Calmette-Guérin.
Vaccine. 2011 29(40):6881-7.
Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives
Yasuhiro Horita, Takemasa Takii, Ryuji Kuroishi, Taku Chiba, Kenji Ogawa,
Laurent Kremer, Yasuo Sato, YooSa Lee, Tomohiro Hasegawa and Kikuo Onozaki
Bioorganic & Medicinal Chemistry Letters 21899-903 2011
Etiological role of cigarette smoking in rheumatoid arthritis: Nasal exposure
to cigarette smoke condensate extracts augments the development of collagen-induced
arthritis in mice.
Okamoto S, Adachi M, Chujo S, Yamada K, Akita K, Itoh S, Takii T, Hayakawa K, Onozaki K.
Biochem Biophys Res Commun. 404(4):1088-92 (2011)
2010
Dual Mode of Regulation of Cell Division Cycle 25 A Protein by TRB3
Satoshi Sakai, Nobumichi Ohoka, Kikuo Onozaki, Masatoshi Kitagawa, Makoto
Nakanishi, Hidetoshi Hayashi
Biol. Phar. Bull.33,1112-1126 (2010).
Cigarette smoke condensate extracts augment collagen-induced arthritis in mice.
Satomi Chujo, Syosuke Okamoto, Ryouhei Sunahara, Miki Adachi, Kyohei Yamada,
Hidetoshi Hayashi, Takemasa Takii, Kazuichi Hayakawa, Kikuo Onozaki
Int. Immunopharmacol. 10,1194-1199 (2010)
Effectiveness of BCG vaccination to aged mice
Tsukasa Ito, Takemasa Takii, Mitsuo Maruyama, Daisuke Hayashi, Takeshi
Wakao, Azusa Asai, Yasuhiro Horita, Keiichi Taniguchi, Ikuya Yano, Saburo
Yamamoto and Kikuo Onozaki
Immunity & Ageing 7(12) 2010
Comparable Study on Biochemical Characteristics among Mycobacterium bovis BCG Sub-strains
Hayashi D, Takii T, Mukai T, Makino M, Yasuda E, Horita Y, Yamamoto R,
Fujiwara A, Kanai K, Kondo M, Kawarazaki A, Yano I, Yamamoto S, Onozaki
K.
FEMS Microbiology Letters 306(2) 103-109 2010
Halophilic beta-lactamase as a new solubility- and folding-enhancing tag
protein: production of native human interleukin 1alpha and human neutrophil
alpha-defensin
Tokunaga H, Saito S, Sakai K, Yamaguchi R, Katsuyama I, Arakawa T, Onozaki K, Arakawa T, Tokunaga M.
Appl Microbiol Biotechnol. 2010 86(2):649-658.
IL-1-induced ERK1/2 activation up-regulates p21Waf1/Cip1 protein by inhibition
of degradation via ubiquitin independent pathway in human melanoma cells
A375
Tomohiro Arakawa, Hidetoshi Hayashi, Saotomo Itoh, Takemasa Takii, Kikuo
Onozaki.
Biochemical and Biophysical Research Communications. 2010 392(3) 369-72
「メラノーマ細胞株A375のIL-1による増殖抑制が細胞周期調節タンパク質p21の安定性の増大によることを示しました」
Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and
degradation of TRB3
Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
Biochem Biophys Res Commun. 392(3):289-294, 2010.
Staphylococcal superantigen-like protein 10 (SSL10) binds to human immunoglobulin G (IgG) and inhibits complement activation via the classical pathway
Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T.
Molecular Immunology. 2010 47(4):932-938.
「黄色ブドウ球菌の産生するスーパー抗原様タンパク質SSL10がIgGのFc部分に結合し，古典経路による補体活性化を抑制することを見出しました」
2009
Etiological and biological aspects of cigarette smoking in rheumatoid arthritis
Onozaki K
Inflamm Allergy Drug Targets. 2009 8(5):364-8.
Synthesis of new sugar derivatives and evaluation of their antibacterial
activities against Mycobacterium tuberculosis
Horita Y, Takii T, Chiba T, Kuroishi R, Maeda Y, Kurono Y, Inagaki E, Nishimura
K, Yamamoto Y, Abe C, Mori M, Onozaki K.
Bioorganic & Medicinal Chemistry Letters 2009 19(22):6313-6
「治療薬の少ない多剤耐性結核菌に対して抗菌活性のある新規アミノ糖化合物を合成しました」
Comparable Studies of Immunostimulating Activities In Vitro among Mycobacterium bovis bacillus Calmette-Guéin (BCG) Sub-strains
Hayashi D, Takii T, Fujiwara N, Fujita Y, Ikuya Y, Yamamoto S, Kondo M,
Yasuda E, Inagaki E, Kanai K, Fujiwara A, Kawarazaki A, Chiba T, Onozaki
K.
FEMS Immunology & Medical Microbiology 2009 56(2):116-28.
Separation and molecular characterization of mycolic acid from the cell
wall skeleton of Mycobacterium bovis BCG Tokyo 172 (SMP-105) and BCG substrains by normal-phase high performance
liquid chromatography and liquid chromatography/mass spectrometry
Uenishi Y, Takii T, Yano I, Sunagawa M.
J Microbiol Methods. 2009 77(3):320-2.
Population Is a Critical Factor for Global Carbon Dioxide Increase
Onozaki K
J Health Sci. 2009 55(1):125-7
An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes
Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.
Am J Physiol Cell Physiol. 297(5):C1082-90, 2009.
2008
Cigarette smoke condensate upregulates the gene and protein expression
of proinflammatory cytokines in human fibroblast-like synoviocyte line
Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko
M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.
J Interferon Cytokine Res. 2008 28(8):509-21
「たばこの主流煙濃縮物がヒト滑膜細胞株からの炎症性サイトカインの産生を亢進することを見出しました」
Inhibition of human immunodeficiency virus type 1 replication by blocking IkappaB kinase with noraristeromycin
Asamitsu K, Yamaguchi T, Nakata K, Hibi Y, Victoriano AF, Imai K, Onozaki
K, Kitade Y, Okamoto T.
J Biochem. 2008 144(5):581-9.
The interaction with Sp1 and reduction in the activity of histone deacetylase
1 are critical for the constitutive gene expression of IL-1 alpha in human
melanoma cells
Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.J Leukoc Biol. 2008 83(1):190-9.
2007
Critical and functional regulation of CHOP (C/EBP homologous protein) through the N-terminal portion
Ohoka N, Hattori T, Kitagawa M, Onozaki K, Hayashi H.
J Biol Chem. 2007 282(49):35687-94.
Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha
mRNA expression in rheumatoid fibroblast-like synovial cells
Itoh Y, Hayashi H, Xu J, Takii T, Miyazawa K, Ariga H, Akahoshi T, Waguri-Nagaya
Y, Otsuka T, Okamoto T, Onozaki K.
Biol Pharm Bull. 2007 30(6):1140-3.
Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat
T-lymphocyte
Morimoto T, Ohya S, Hayashi H, Onozaki K, Imaizumi Y.
J Pharmacol Sci. 2007 104(1):94-8.
Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial
evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureus
Chiba T, Takii T, Nishimura K, Yamamoto Y, Morikawa H, Abe C, Onozaki K.
Bioorg Med Chem Lett. 2007 17(9):2487-91.
17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like
synovial cells through estrogen receptor alpha (ERalpha) and augmentation
of transcriptional activity of Sp1 by dissociating histone deacetylase
2 from ERalpha
Itoh Y, Hayashi H, Miyazawa K, Kojima S, Akahoshi T, Onozaki K.
J Immunol. 2007 178(5):3059-66.
Synthesis of glycosylated human tumor necrosis factor alpha coupled with
N-acetylneuraminic acid
Hayashi A, Chiba T, Hayashi H, Sasayama S, Ishiguro T, Onozaki K.
Cancer Immunol Immunother. 2007 56(4):545-53.
N-acetylneuraminic acid coupled human recombinant TNFalpha exhibits enhanced
anti-tumor activity against Meth-A fibrosarcoma and reduced toxicity
Hayashi A, Hayashi H, Chiba T, Sasayama S, Onozaki K.
Cancer Immunol Immunother. 2007 56(4):555-62. .
Synthesis and biological activities in vitro and in vivo of glycosylated
human interleukin-1alpha, neoglyco IL-1alpha, coupled with N -acetylneuraminyl-galactose
Ootsubo M, Chiba T, Kobayashi Y, Hayashi H, Hayashi A, Onozaki K.
Glycoconj J. 2004;20(2):119-31.
Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1
beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor
Tamaki A, Hayashi H, Nakajima H, Takii T, Katagiri D, Miyazawa K, Hirose
K, Onozaki K.
Biol Pharm Bull. 2004 27(3):407-10.
Contribution of the constitutive and inducible degradation of Smad3 by the ubiquitin-proteasome pathway to transforming growth factor-beta signaling
Inoue Y, Kitagawa M, Onozaki K, Hayashi H.
Interferon Cytokine Res. 2004 24(1):43-54.