Publication (En)

Several Japanese publications are translated in English (updated in Mar. 29, 2018).


・Tagami T, Ando M, Nagata N, Goto E, Yoshimura N, Takeuchi T, Noda T, Ozeki T. Fabrication of naftopidil-loaded tablets using a semi-solid extrusion-type 3D printer, and the characteristics of the printed hydrogel and resulting tablets. J Pharm Sci. Accepted. (2018)

・Takeuchi T, Tagami T, Fukushige K, Ozeki T. Useful properties of siRNA-coated gold nanoparticles as a mini-nanocarrier platform for intraocular administration. Journal of Drug Delivery Science and Technology. (2018) Accepted.

・Morikawa Y, Tagami T, Hoshikawa A, Ozeki T. The use of an efficient microfluidic mixing system for generating stabilized polymeric nanoparticles for controlled drug release. Biol Pharm Bull. (2018) 41(6):899-907.

・Tagami T, Nagata N, Hayashi N, Ogawa E, Fukushige K, Sakai N, Ozeki T. Defined drug release from 3D-printed composite tablets consisting of drug-loaded polyvinylalcohol and a water-soluble or water-insoluble polymer filler. Int J Pharm. (2018) 543(1-2):361-367.

・Hoshikawa A, Nagira M, Tane M, Fukushige K, Tagami T, Ozeki T. Preparation of curcumin-containing α-, β-, and γ-cyclodextrin/polyethylene glycol-conjugated gold multifunctional nanoparticles and their in vitro cytotoxic effects on A549 cells. Biol Pharm Bull. (2018) 41(6):908-914.

・Fuse T, Tagami T, Tane M, Ozeki T. Effective light-triggered contents release from helper lipid-incorporated liposomes co-encapsulating gemcitabine and a water-soluble photosensitizer. Int J Pharm. (2018) 540: 50-56.

・Ibrahim S, Tagami T, Kishi T, Ozeki T. Curcumin marinosomes as promising nano-drug delivery systems for lung cancer. Int J Pharm. (2018) 540: 40-49.

・Wallin M, Tagami T, Chen L, Yang M, Chan HK. Pulmonary drug delivery to older people. Adv Drug Deliv Rev. Review. E-published.

・Noda T, Okuda T, Mizuno R, Ozeki T, Okamoto H. Two-Step Sustained-Release PLGA/Hyaluronic Acid Gel Formulation for Intra-articular Administration.Biol Pharm Bull. (2018) 41(6):937-943.

・Alenezi A, Naito Y, Terukina T, Prananingrum W, Jinno Y, Tagami T, Ozeki T, Galli S, Jimbo R. Controlled release of clarithromycin from PLGA microparticles enhances bone regeneration in rabbit calvaria defects. J Biomed Mater Res Part B (2018) 106(1):201-208.

・Tagami T, Ozeki T. Preparation of nanocomposite particles and the application for inhalation formulation. Development of inhalation formulation and device. CMC publishing Co. Ltd. (2018) (Japanese) In press.

・Tagami T, Ozeki T. Biopharmaceutical DDS-Recent studies of controlled release of protein drugs by using biodegradative polymers and hydrogels- CMC publishing Co. Ltd. (2018) (Japanese) In press.

・Tagami T, Ozeki T. Current trend of clinical trials related with nanomedicine. Drug Delivery System- Development of delivery technology for tissue, cells and nucleus for the biopharmaceuticals. CMC publishing Co. Ltd. (2018) p21-32 (Japanese).

・Tagami T, Ozeki T. Pharmaceutical application of 3D printing technology: Mini-review of 3D printed tablets and medicine. Japan Society of Pharmaceutical Machinery and Engineering. (2018) 27(1):57-62 (Japanese).

・Tagami T., Ozeki T. Mini-lesson of lab preparation of 3D-printed polymer-based tablets by using fused deposition modeling type 3D printer. Japan Society of Pharmaceutical Machinery and Engineering. (2018) 27(1):51-56 (Japanese).

・Tagami T, Ozeki T. Chalkface to graduate students learning nanomedicine. Farumashia. (2018) 54(1):51-53 (Japanese).


・Ibrahim S, Tagami T, Ozeki T. Effective-loading of platinum-chloroquine into PEGylated neutral and cationic liposomes as a drug delivery system for resistant malaria parasites. Biol Pharm Bull. (2017) 40: 815-823.

・Tagami T, Ozeki T. Recent trend of carrier-based drug delivery in clinical trials. J Pharm Sci. (2017) 106(9): 2219-2226. Commentary.

・Fukushige K, Tagami T, Ozeki T. The offset effect of a hyaluronic acid coating to cationic carriers containing siRNA: Alleviated cytotoxicity and retained gene silencing in vitro. Journal of Drug Delivery Science and Technology. (2017) 39: 435-441.

・Noda T, Okuda T, Ban K, Mizuno R, Tagami T, Ozeki T, Okamoto H. Development of intra-knee joint sustained release gel formulation and evaluation of its pharmacological efficiency in rat. Biol Pharm Bull. (2017) 40(6):830-836.

・Hoshikawa A, Tagami T, Morimura C, Fukushige K, Ozeki T. Ranibizumab biosimilar/ polyethyleneglycol-conjugated gold nanoparticles as a novel drug delivery platform for age-related macular degeneration. Journal of Drug Delivery Science and Technology. (2017) 38:45-50.

・Tagami T, Fukushige K, Ogawa E, Hayashi N, Ozeki T. 3D printing factors important for the fabrication of polyvinylalcohol filament-based tablets. Biol Pharm Bull. (2017) 40(3):357-364.

・Taki M, Tagami T, Ozeki T. Preparation of polymer-blended quinine nanocomposite particles by spray drying and assessment of their instrumental bitterness-masking effect using a taste sensor. Drug Dev Ind Pharm. (2017) 43(5): 715-722.

・Tagami T, Ando Y, Ozeki T. Fabrication of liposomal doxorubicin exhibiting ultrasensitivity against phospholipase A2 for efficient pulmonary drug delivery to lung cancers. Int J Pharm. (2017) 517: 35-41.

・Yoshimura M, Miyake M, Kawato T, Bando M, Toda M, Kato Y, Fukami T, Ozeki T. Impact of the Dissolution Profile of the Cilostazol Cocrystal with Supersaturation on the Oral Bioavailability. Cryst. Growth Des. (2017) 17 (2):550–557.

・Tanetsugu T, Tagami T, Terukina T, Ogawa T, Ohta M, Ozeki T. Development of sustainable release system for ranibizumab biosimilar using poly(lactic-co-glycolic acid) biodegradable polymer based microspheres as a platform. Biol. Pharm. Bull. (2017) 40(2) :145-150.

・Tagami T, Ozeki T. Development of DDS technology by using PLGA particles. Applicaiton for advanced biopharmaceuticals of novel DDS technology. Technical Information Institute (2017) 395-400 (Japanese).

・Tagami T, Ozeki T. DDS technology of nano/micro particles and clinical application. Organ Biology. (2017) 24(1):54-60 (Japanese).

・Tagami T, Ozeki T. Preparation of solid dispersion by using spray drying method. Formulation technology of poorly water-soluble drugs. (2017) 17(8):29-31 (Japanese).


・Otsuka M, Maeno Y, Fukami T, Inoue M, Tagami T, Ozeki T. Solid dispersions of efonidipine hydrochloride ethanolate with improved physicochemical and pharmacokinetic properties prepared with microwave treatment. Eur J Pharm Biopharm. (2016) 108: 25-31.

・Taki M, Tagami T, Fukushige K, Ozeki T. Fabrication of nanocomposite particles using a two-solution mixing-type spray nozzle for use in an inhaled curcumin formulation. Int J Pharm. (2016) 11(1):104-10.

・Nakane D, Tagami T, Inomata T, Ichikawa Y, Nakada A, Ozeki T, Masuda H. Dissolution of water-insoluble curcumin by femtosecond-laser ablation in the presence of cyclodextrins and its cytotoxic bioactivity against lung cancer cells. Chemistry letters. (2016) 45(9):1072-1074.

・Miyahara S, Tagami T, Wakabayashi R, Miyazaki I, Murata N, Takahashi Y, Ohkubo H, Ozeki T. Manufacturing control of drugs in opaque packages using an X-ray scanning system and assessment of the irradiation effects on the drug qualities. Japan Society of Pharmaceutical Machinery and Engineering. (2016) 25(2):112-118.

・Terukina T, Naito Y, Tagami T, Morikawa, Y, Henmi Y, Pranaingrum W, Ichikawa T, Ozeki T. The effect of the release behavior of simvastatin from different PLGA particles on bone regeneration in vitro and in vivo: comparison of simvastatin-loaded PLGA microparticles and nanospeheres. Journal of Drug Delivery Science and Technology. (2016) 33: 136-142.

・Nishiyama T, Ogata T, Ozeki T. Preparation of bitter taste-masking granules of lafutidine for orally disintegrating tablets using water-insoluble/soluble polymer combinations. Journal of Drug Delivery Science and Technology. (2016) 32: 38-42.

・Tagami T, Taki M, Ozeki T. Nanoparticulate drug delivery systems to overcome the blood-brain barrier. Nanomaterials in Pharmacology. Springer. Invited review (2016) Chapter 17: 333-348.

・Tagami T. Ozeki T. Progress of DDS technology via transpulmonary route: a mini review about inhalable insulin. Drug Delivery System. (2016) 31(5): 432-439 (Japanese).


・Tagami T, Yanai H, Terada Y, Ozeki T. Evaluation of phosphatidylserine-specific peptide-conjugated liposomes using a model system of malaria-infected erythrocytes. Biol. Pharm. Bull. (2015) 38(10):1649-51.

・Tagami T, Kubota M, Ozeki T. Effective Remote Loading of Doxorubicin into DPPC/Poloxamer 188 Hybrid Liposome to Retain Thermosensitive Property and the Assessment of Carrier-Based Acute Cytotoxicity for Pulmonary Administration. J Pharm Sci. (2015) 104(11):3824-32.

・Mizusako H, Tagami T, Hattori K, Ozeki T. Active Drug Targeting of a Folate-Based Cyclodextrin-Doxorubicin Conjugate and the Cytotoxic Effect on Drug-Resistant Mammary Tumor Cells In Vitro. J Pharm Sci. (2015) 104(9):2934-40.

・Uehara K, Tagami T, Miyazaki I, Murata N, Takahashi Y, Ohkubo H, Ozeki T. Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment. Drug Dev Ind Pharm. (2015) 41(6):953-8.

・Otsuka M, Maeno Y, Fukami T, Inoue M, Tagami T, Ozeki T. Developmental considerations for ethanolates with regard to stability and physicochemical characterization of efonidipine hydrochloride ethanolate. CrystEngComm. (2015) 17, 7430-7436.

・Tagami T, Ozeki T. Protocol for DDS carrier. Chapter: Biocompatible Nanosphere. CMC publishing Co., Ltd. p85-88. Published in Aug. 2015 (Japanese).


・Maeno Y, Fukami T, Kawahata M, Yamaguchi K, Tagami T, Ozeki T, Suzuki T, Tomono K. Novel pharmaceutical cocrystal consisting of paracetamol and trimethylglycine, a new promising cocrystal former. Int J Pharm. (2014) 473(1-2):179-86.

・Ozeki T, Tagami T. Drug/polymer nanoparticles prepared using unique spray nozzles and recent progress of inhaled formulation. Asian J Pharm Sci. (2014) 9(5):236-43. Review.

・Tagami T, Imao Y, Ito S, Nakada A, Ozeki T. Simple and effective preparation of nano-pulverized curcumin by femtosecond laser ablation and the cytotoxic effect on C6 rat glioma cells in vitro. Int J Pharm. (2014) 468(1-2):91-6.

・Naito Y, Terukina T, Galli S, Kozai Y, Vandeweghe S, Tagami T, Ozeki T, Ichikawa T, Coelho PG, Jimbo R. The effect of simvastatin-loaded polymeric microspheres in a critical size bone defect in the rabbit calvaria. Int J Pharm. (2014) 461(1-2):157-62.

・Tagami T, Ozeki T. Novel drug formulation/drug delivery research produced by the fusion/collaboration with different field. Pharm Tech Japan. (2014) 30(11): 135-140 (Japanese).

・Tagami T, Ozeki T. Trend of inhalation formulation and application of nanocomposite particles prepared by two-solution mixing type spray nozzle. Medicine and Drug Journal. (2014) 50(9): 67-72 (Japanese).